{"id":"W1979867324","doi":"10.1371/journal.pone.0029798","title":"Mitochondrial Electron Transport Is the Cellular Target of the Oncology Drug Elesclomol","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Human Genome Research Institute; Ligue Contre le Cancer; Canadian Institutes of Health Research; Association pour la Recherche sur le Cancer","keywords":"Drug; Mitochondrion; Biology; Mechanism of action; Drug development; Programmed cell death; Cancer research; Chemistry; Computational biology; Pharmacology; Cell biology; Apoptosis; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001943504,0.0001382523,0.0002073101,0.00001934221,0.0001011498,0.000003222108,0.0003034531,0.0001956128,0.0002852146],"category_scores_gemma":[0.00005657953,0.00008669311,0.0001629669,0.00009422213,0.0001355578,0.000003607041,0.00005104531,0.0002057488,0.00003280722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001461098,"about_ca_system_score_gemma":0.00009395801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001843411,"about_ca_topic_score_gemma":0.00002606215,"domain_scores_codex":[0.9988195,0.0002046657,0.0002452226,0.0002086169,0.0001946285,0.0003273231],"domain_scores_gemma":[0.9992013,0.00002401648,0.0001275588,0.0005054771,0.00007353119,0.00006814517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001718434,0.0005696315,0.005907028,0.00001656382,0.0001261026,4.385218e-7,0.000330746,0.000001658231,0.9877248,0.0001540597,0.004960081,0.00003708912],"study_design_scores_gemma":[0.0004204163,0.0001828265,0.0006961841,0.000007555463,0.0001115945,0.000004033534,0.00003871203,0.000003794626,0.9117171,0.00006050036,0.08665859,0.00009875555],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930134,0.0009337289,0.0003821646,0.001332854,0.0007373004,0.0004413844,0.00003106357,0.000009691885,0.003118421],"genre_scores_gemma":[0.9901966,0.0001146203,0.001099935,0.001320416,0.001710223,0.00005177913,0.00006211189,0.00002408902,0.00542025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08169851,"threshold_uncertainty_score":0.3535242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01689125905553686,"score_gpt":0.2208130308017868,"score_spread":0.20392177174625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}