{"id":"W1979889746","doi":"10.1016/s0006-2952(01)00820-6","title":"In vivo up-regulation of aryl hydrocarbon receptor expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in a dioxin-resistant rat model☆1☆Portions of this work were presented at the 20th International Symposium on Halogenated Environmental Organic Pollutants & POPS, Monterey, California (August 13–17, 2000).1Abbreviations: AHR, aryl hydrocarbon receptor; AP, alkaliSne phosphatase; ARNT, aryl hydrocarbon receptor nuclear translocator protein; dNTP, 2′-deoxynucleoside 5′-triphosphate; DRE, dioxin responsive element; H/W, Han/Wistar (Kuopio); L-E, Long-Evans (Turku AB); PCB, polychlorinated biphenyl; PCR, polymerase chain reaction; RT, reverse transcription; SD, Sprague Dawley; and TCDD, 2,3,7,8-tetrachlorodibenzo-pdioxin.","year":2001,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Canada Research Chairs","funders":"","keywords":"Aryl hydrocarbon receptor; In vivo; Internal medicine; Endocrinology; Cytosol; Receptor; Toxicity; Chemistry; Gene expression; Downregulation and upregulation; Ligand (biochemistry); Basal (medicine); In vitro; Messenger RNA; Biology; Biochemistry; Gene; Enzyme; Transcription factor; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.001217572,0.001425399,0.001423243,0.0006512812,0.0004059398,0.00007084919,0.001260135,0.000987618,0.009365974],"category_scores_gemma":[0.0002819921,0.001361361,0.0004086254,0.002062934,0.001093673,0.001026342,0.0004082596,0.001424752,0.0001158975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00348393,"about_ca_system_score_gemma":0.0001995552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001720184,"about_ca_topic_score_gemma":0.0005756871,"domain_scores_codex":[0.9909877,0.000600063,0.002771155,0.002280278,0.001725877,0.00163498],"domain_scores_gemma":[0.9959961,0.0003741808,0.001587537,0.001195648,0.00003659676,0.0008099648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0148811,0.00250877,0.001740321,0.00005422313,0.0003008162,0.00004541636,0.001009115,0.0004777993,0.9538476,0.000005033977,0.02468328,0.0004464648],"study_design_scores_gemma":[0.007609155,0.000516335,0.002699074,0.0004362938,0.0002785026,0.00005789321,0.0002847258,0.003275838,0.9761707,0.00003328642,0.007400884,0.001237308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796646,0.00389492,0.0000860395,0.003862364,0.000917959,0.003624292,0.0076704,0.0001879934,0.00009140723],"genre_scores_gemma":[0.9929333,0.003012086,0.0001866089,0.0006184724,0.0001724356,0.0002783667,0.001145004,0.0002479803,0.001405708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02232305,"threshold_uncertainty_score":0.9998496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008043375507450327,"score_gpt":0.2233326024309989,"score_spread":0.2152892269235485,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}