{"id":"W1979889746","doi":"10.1016/s0006-2952(01)00820-6","title":"In vivo up-regulation of aryl hydrocarbon receptor expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in a dioxin-resistant rat model☆1☆Portions of this work were presented at the 20th International Symposium on Halogenated Environmental Organic Pollutants & POPS, Monterey, California (August 13–17, 2000).1Abbreviations: AHR, aryl hydrocarbon receptor; AP, alkaliSne phosphatase; ARNT, aryl hydrocarbon receptor nuclear translocator protein; dNTP, 2′-deoxynucleoside 5′-triphosphate; DRE, dioxin responsive element; H/W, Han/Wistar (Kuopio); L-E, Long-Evans (Turku AB); PCB, polychlorinated biphenyl; PCR, polymerase chain reaction; RT, reverse transcription; SD, Sprague Dawley; and TCDD, 2,3,7,8-tetrachlorodibenzo-pdioxin.","year":2001,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Canada Research Chairs","funders":"","keywords":"Aryl hydrocarbon receptor; In vivo; Internal medicine; Endocrinology; Cytosol; Receptor; Toxicity; Chemistry; Gene expression; Downregulation and upregulation; Ligand (biochemistry); Basal (medicine); In vitro; Messenger RNA; Biology; Biochemistry; Gene; Enzyme; Transcription factor; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004141815,0.0008600901,0.0003789956,0.001123134,0.0003564269,0.0004652605,0.0003086013,0.0004528161,0.003469975],"category_scores_gemma":[0.000171775,0.0005147519,0.000684172,0.0004514091,0.0006291703,0.000384911,0.0002407044,0.00131699,0.001695053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007220801,"about_ca_system_score_gemma":0.0003914265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001936598,"about_ca_topic_score_gemma":0.003666806,"domain_scores_codex":[0.9995332,0.00005007853,0.00003007595,0.0001475851,0.00007947509,0.0001596495],"domain_scores_gemma":[0.9995547,0.00006508717,0.00009676029,0.0000680817,0.0000514066,0.0001640268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003324815,0.0001405898,0.0001884875,0.00001532063,0.000006516872,0.00005485854,0.00002281394,0.00003048287,0.998548,0.00007566003,0.00007077821,0.0005139861],"study_design_scores_gemma":[0.00008264866,0.001392383,0.005588988,0.000007477512,0.00004088613,0.0001859937,0.00006441658,0.0004877403,0.9908519,0.000072509,0.001214627,0.00001043563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907024,0.001396375,0.00338245,0.0002171672,0.0001657123,0.00003943064,0.001383078,0.0002163868,0.0024971],"genre_scores_gemma":[0.9576128,0.002170854,0.004501731,0.000190253,0.0000877393,0.000144917,0.004402126,0.0001675252,0.03072211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003469975,"threshold_uncertainty_score":0.01160824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008043375507450327,"score_gpt":0.2233326024309989,"score_spread":0.2152892269235485,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}