{"id":"W1979916062","doi":"10.1111/j.1365-2141.2009.07889.x","title":"A Phase I/II study of the safety and efficacy of the addition of sirolimus to tacrolimus/methotrexate graft <i>versus</i> host disease prophylaxis after allogeneic haematopoietic cell transplantation in paediatric acute lymphoblastic leukaemia (ALL)","year":2009,"lang":"en","type":"article","venue":"British Journal of Haematology","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; CancerCare Manitoba","funders":"National Cancer Institute; University of Utah","keywords":"Cumulative incidence; Medicine; Sirolimus; Transplantation; Internal medicine; Immunosuppression; Tacrolimus; Hematopoietic stem cell transplantation; Hazard ratio; Graft-versus-host disease; Population; Cohort; Total body irradiation; Gastroenterology; Surgery; Chemotherapy; Cyclophosphamide; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002790223,0.001845157,0.002109273,0.0005234964,0.0004190341,0.0008115395,0.001026328,0.001124801,0.002158459],"category_scores_gemma":[0.001630166,0.0006268581,0.00123517,0.0005050061,0.001719277,0.0007639163,0.0003892891,0.003488443,0.000486957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008503319,"about_ca_system_score_gemma":0.002151589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008220021,"about_ca_topic_score_gemma":0.001214446,"domain_scores_codex":[0.9987804,0.0007394225,0.00006255616,0.0001710868,0.0001047793,0.0001417502],"domain_scores_gemma":[0.9981679,0.0003770514,0.0004259431,0.0002005318,0.00007823105,0.0007503405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7553444,0.1161245,0.009128437,0.0004449208,0.0007811274,0.0003992367,0.0003511321,0.001636796,0.05017571,0.0003217716,0.001443109,0.06384882],"study_design_scores_gemma":[0.3024788,0.6848515,0.007008328,0.00001444883,0.0002469904,0.0002194069,0.00002849043,0.0005699121,0.00359308,0.0001188633,0.0008529882,0.00001726554],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954302,0.0006253438,0.0005654356,0.0001751383,0.00006253861,0.002086419,0.000373692,0.00004183583,0.0006393223],"genre_scores_gemma":[0.989312,0.001108384,0.003125667,0.0006153398,0.0002431569,0.003236771,0.001326264,0.00003184655,0.00100057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002790223,"threshold_uncertainty_score":0.01475632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008794542205020473,"score_gpt":0.2733709089477738,"score_spread":0.2645763667427533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}