{"id":"W1979916062","doi":"10.1111/j.1365-2141.2009.07889.x","title":"A Phase I/II study of the safety and efficacy of the addition of sirolimus to tacrolimus/methotrexate graft <i>versus</i> host disease prophylaxis after allogeneic haematopoietic cell transplantation in paediatric acute lymphoblastic leukaemia (ALL)","year":2009,"lang":"en","type":"article","venue":"British Journal of Haematology","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; CancerCare Manitoba","funders":"National Cancer Institute; University of Utah","keywords":"Cumulative incidence; Medicine; Sirolimus; Transplantation; Internal medicine; Immunosuppression; Tacrolimus; Hematopoietic stem cell transplantation; Hazard ratio; Graft-versus-host disease; Population; Cohort; Total body irradiation; Gastroenterology; Surgery; Chemotherapy; Cyclophosphamide; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005870566,0.0002435763,0.00105896,0.00037297,0.0000869949,0.00001225671,0.0004066155,0.0001557008,0.00002765313],"category_scores_gemma":[0.0005976785,0.0001779297,0.0002737821,0.000835434,0.0002988903,0.0001152411,0.0001239576,0.0004194813,8.987454e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002010373,"about_ca_system_score_gemma":0.0006872932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007447667,"about_ca_topic_score_gemma":0.00009040977,"domain_scores_codex":[0.9963987,0.0006638225,0.001433733,0.0003068786,0.0008038024,0.0003930324],"domain_scores_gemma":[0.9975388,0.000610813,0.0008285983,0.0003774237,0.000378936,0.0002654369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.3996728,0.06814973,0.06037666,0.009939843,0.003399168,0.1390516,0.03386797,0.003718926,0.2278329,0.0001266151,0.00186927,0.05199458],"study_design_scores_gemma":[0.1426188,0.02904027,0.7434272,0.003022766,0.004751058,0.05275179,0.00101776,0.0003865418,0.0222121,0.0001888605,0.00005380357,0.0005290986],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964963,0.001076222,0.0001777069,0.0004852823,0.0001689435,0.001362921,0.0002063799,0.000005839727,0.00002046147],"genre_scores_gemma":[0.9987593,0.0007391243,0.0002100682,0.0001771183,0.00004710588,0.00001847661,0.000007712706,0.00002656507,0.00001447072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6830505,"threshold_uncertainty_score":0.7255763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008794542205020473,"score_gpt":0.2733709089477738,"score_spread":0.2645763667427533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}