{"id":"W1979943751","doi":"10.1016/j.bmcl.2014.09.024","title":"Synthesis of new 1-(4-methane(amino)sulfonylphenyl)-5-(4-substituted-aminomethylphenyl)-3-trifluoromethyl-1H-pyrazoles: A search for novel nitric oxide donor anti-inflammatory agents","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and Reactions of Organic Compounds","field":"Chemistry","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Trifluoromethyl; Chemistry; Nitric oxide; Pyrazole; Medicinal chemistry; Piperazine; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001187093,0.0008685853,0.001333773,0.000311293,0.0002750907,0.00007682158,0.001578481,0.0005923397,0.00157318],"category_scores_gemma":[0.001792899,0.0008330019,0.0005945321,0.0007703174,0.000554233,0.0002166688,0.0002523194,0.0007278699,0.00004736215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004980649,"about_ca_system_score_gemma":0.0005724262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003343916,"about_ca_topic_score_gemma":0.000002557751,"domain_scores_codex":[0.9949067,0.00004955016,0.001436512,0.001222751,0.001238394,0.001146053],"domain_scores_gemma":[0.9950148,0.001695536,0.0007206475,0.001563469,0.0002658098,0.0007397495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001391614,0.0003239751,0.003419797,0.001352744,0.000467983,0.00001437879,0.0001761704,0.000009349925,0.9855697,0.0000185009,0.002100757,0.006407496],"study_design_scores_gemma":[0.002414783,0.00001655395,0.006945153,0.0004959594,0.0005821196,0.0001456632,0.0006967821,0.0001566,0.9757738,0.00001358585,0.01191913,0.000839848],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910942,0.0005524319,0.004748985,0.001579507,0.0002732362,0.0003058782,0.000136172,0.0002574432,0.001052137],"genre_scores_gemma":[0.9938561,0.000144881,0.002903037,0.0002760501,0.001730778,0.00007378891,0.00009008095,0.0001872018,0.0007380315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009818372,"threshold_uncertainty_score":0.9994121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02300719088895404,"score_gpt":0.2441513559294197,"score_spread":0.2211441650404657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}