{"id":"W1979946545","doi":"10.1038/nature11017","title":"The landscape of cancer genes and mutational processes in breast cancer","year":2012,"lang":"en","type":"article","venue":"Nature","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1728,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Vlaamse regering; National Institute for Health and Care Research; Biotechnology and Biological Sciences Research Council; Fonds Wetenschappelijk Onderzoek; National Cancer Institute; Cancer Research UK; Wellcome Trust","keywords":"Biology; Breast cancer; Genetics; Gene; Cancer; Germline mutation; Mutation; Somatic cell; Copy-number variation; Germline; Cancer research; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004013312,0.0001074153,0.0002961234,0.0007569718,0.0002751652,0.001331376,0.0002844303,0.000506599,0.001400971],"category_scores_gemma":[0.001006782,0.0001588283,0.0001316121,0.0007156207,0.0007046218,0.00094983,0.0003294695,0.0004645379,0.0002611993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006507037,"about_ca_system_score_gemma":0.0003000563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009391243,"about_ca_topic_score_gemma":0.001790464,"domain_scores_codex":[0.9997404,0.00006065171,0.00001074493,0.00006235093,0.00008108947,0.00004478041],"domain_scores_gemma":[0.999719,0.0001293448,0.00005341972,0.00002106499,0.00003975772,0.00003736414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001245345,0.0001474863,0.2180938,0.000394983,0.0001889834,0.001542477,0.001009123,0.01073283,0.3993531,0.07878086,0.006120448,0.2823905],"study_design_scores_gemma":[0.00005145928,0.0003438484,0.6996881,0.0001341017,0.0002040861,0.005445975,0.001821936,0.01583269,0.03360136,0.1656665,0.07713491,0.000075038],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9427286,0.03264006,0.005820044,0.007449912,0.00005073653,0.000008684857,0.0006306064,0.0001049489,0.01056647],"genre_scores_gemma":[0.9886148,0.007811931,0.00111214,0.0006153335,0.00008267198,0.00000795523,0.0001320218,0.00002832747,0.001594935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001400971,"threshold_uncertainty_score":0.004721224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003739116149259522,"score_gpt":0.2599361025344896,"score_spread":0.25619698638523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}