{"id":"W1979972501","doi":"10.1038/onc.2008.144","title":"Loss of responsiveness to IGF-I in cells with reduced cathepsin L expression levels","year":2008,"lang":"en","type":"article","venue":"Oncogene","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"Shriners Hospitals for Children - Canada; Royal Victoria Hospital; Royal Victoria Regional Health Centre; McGill University","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Science Foundation","keywords":"Biology; Cathepsin; Cathepsin L; Cathepsin D; Cathepsin S; Cathepsin B; Growth factor; Cell growth; Intracellular; Cell biology; Cell culture; Receptor; Cancer research; Endocrinology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002557561,0.0005957196,0.0005110194,0.0006225906,0.0003373633,0.0008610339,0.0004436682,0.0005307571,0.003750618],"category_scores_gemma":[0.0003301666,0.0002656737,0.0006921244,0.0004638156,0.0006443565,0.0004788025,0.0003446276,0.001465019,0.001147195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009035467,"about_ca_system_score_gemma":0.0006523457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00417386,"about_ca_topic_score_gemma":0.003311258,"domain_scores_codex":[0.9995978,0.00004148307,0.0000567621,0.00006614918,0.0001113561,0.0001264906],"domain_scores_gemma":[0.9994664,0.0001730339,0.0000661921,0.00011108,0.00005217036,0.0001311221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001558008,0.00004023428,0.0001725214,0.00001740701,0.000006226021,0.0000759882,0.00002071615,0.00004579357,0.9987844,0.0001205224,0.0000579044,0.0005025764],"study_design_scores_gemma":[0.00001491988,0.0001383857,0.00311864,0.00000260574,0.0000119536,0.0002945116,0.00007197247,0.0005825566,0.9939756,0.0000358162,0.00174546,0.000007608637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881861,0.001035136,0.003830822,0.0003807622,0.0002199322,0.00005854685,0.002525098,0.0003404772,0.003423092],"genre_scores_gemma":[0.9885301,0.0003577172,0.002174687,0.00009171697,0.00002066092,0.00008451878,0.002037142,0.00006498561,0.006638546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00417386,"threshold_uncertainty_score":0.01254708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0187635596602134,"score_gpt":0.252947764123272,"score_spread":0.2341842044630586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}