{"id":"W1979980397","doi":"10.1021/mp3004995","title":"Multiplexed Evaluation of Serum and CSF Pharmacokinetics of Brain-Targeting Single-Domain Antibodies Using a NanoLC–SRM-ILIS Method","year":2012,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"","keywords":"In vivo; In vitro; Pharmacokinetics; Single-domain antibody; Chemistry; Antibody; Phage display; Biophysics; Pharmacology; Peptide; Biology; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000832449,0.0006271698,0.000368752,0.0006015446,0.0001608471,0.0003970289,0.0003395293,0.0003706354,0.0006281006],"category_scores_gemma":[0.0005222054,0.0002634437,0.0001996848,0.0002347895,0.0002839332,0.0002777388,0.0002242525,0.0005080916,0.0003762717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005854233,"about_ca_system_score_gemma":0.0004043159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00113007,"about_ca_topic_score_gemma":0.001650366,"domain_scores_codex":[0.9994807,0.0001047345,0.00004201223,0.0001402755,0.0001780946,0.00005412673],"domain_scores_gemma":[0.9997481,0.00006773774,0.00006803995,0.0000268761,0.00006271525,0.00002664854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000770486,0.00003194077,0.00022535,0.00002689821,0.000007842013,0.00001772292,0.00002335072,0.0001138514,0.9952297,0.00004539559,0.00003741519,0.00416356],"study_design_scores_gemma":[0.000006205872,0.0001420779,0.001107769,0.000002448054,0.0000116802,0.00006315854,0.000008848488,0.003530468,0.9947595,0.00001346579,0.0003471774,0.000007246782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8215688,0.002313673,0.1706082,0.0002059159,0.00006145377,0.0003374917,0.0006284955,0.001649492,0.002626479],"genre_scores_gemma":[0.830493,0.001109357,0.1628473,0.0001595905,0.00003064246,0.000372195,0.0005268339,0.00006848368,0.004392463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00113007,"threshold_uncertainty_score":0.004402459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1374263995447088,"score_gpt":0.4555724229203425,"score_spread":0.3181460233756337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}