{"id":"W1980006164","doi":"10.1039/b303650m","title":"Synthesis and cytotoxicity evaluation of novel C7–C7, C7–N3 and N3–N3 dimers of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benzo[e]indole (seco-CBI) with pyrrole and imidazole polyamide conjugates","year":2003,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"Synthesis and pharmacology of benzodiazepine derivatives","field":"Chemistry","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Indole test; Pyrrole; Imidazole; Stereochemistry; Cytotoxicity; Organic chemistry; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001395811,0.0002883303,0.0001747678,0.00008390766,0.0001162411,0.0001177438,0.0002096133,0.0001590967,0.000801491],"category_scores_gemma":[0.000112168,0.00009250287,0.0001180279,0.0000868424,0.0001581502,0.0001051497,0.0001098753,0.0001924167,0.0002051412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002184519,"about_ca_system_score_gemma":0.0001978968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005535241,"about_ca_topic_score_gemma":0.0009618124,"domain_scores_codex":[0.9998964,0.00002206945,0.000009993962,0.00001978538,0.00002997741,0.00002185],"domain_scores_gemma":[0.9998715,0.00001662691,0.00004221497,0.00001587397,0.00001852686,0.00003530161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000760872,0.0000203402,0.00005366202,0.00001531891,0.000002533933,0.00001578008,0.000005412084,0.0001262874,0.9987274,0.00003097381,0.00001547116,0.0009108361],"study_design_scores_gemma":[0.00001034035,0.0004526775,0.0004409986,0.000001262715,0.000005696101,0.00006523214,0.000003165149,0.0002842969,0.9980762,0.000004236698,0.0006541514,0.000001772084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955298,0.0005854228,0.002187652,0.00001841996,0.00001044389,0.0000470354,0.00008985116,0.00002928413,0.001502104],"genre_scores_gemma":[0.993999,0.0003859137,0.003468227,0.00001661197,0.000005764331,0.00005383989,0.0001811869,0.000008698612,0.001880702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000801491,"threshold_uncertainty_score":0.002681315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01398432813207677,"score_gpt":0.245338624376,"score_spread":0.2313542962439232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}