{"id":"W1980006164","doi":"10.1039/b303650m","title":"Synthesis and cytotoxicity evaluation of novel C7–C7, C7–N3 and N3–N3 dimers of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benzo[e]indole (seco-CBI) with pyrrole and imidazole polyamide conjugates","year":2003,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"Synthesis and pharmacology of benzodiazepine derivatives","field":"Chemistry","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Indole test; Pyrrole; Imidazole; Stereochemistry; Cytotoxicity; Organic chemistry; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008069913,0.0005353687,0.0007918409,0.0000865763,0.0001676499,0.00004508757,0.0002500381,0.0003941297,0.00155699],"category_scores_gemma":[0.0007198894,0.0005226892,0.0001077722,0.000295617,0.0008300433,0.0001493626,0.0001390046,0.0002738309,0.000001911246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007202789,"about_ca_system_score_gemma":0.0002301987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006206554,"about_ca_topic_score_gemma":0.000006588799,"domain_scores_codex":[0.9973871,0.0001154297,0.0006238234,0.0008211363,0.0005843795,0.0004681913],"domain_scores_gemma":[0.9980443,0.0003950054,0.0005556478,0.0004997216,0.0002394573,0.0002659063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000104839,0.0003466586,0.002501595,0.0006951284,0.0004903158,0.000009227376,0.0003369915,0.00001161714,0.9948097,0.00001261018,0.00002246356,0.0006588704],"study_design_scores_gemma":[0.002256991,0.00005443889,0.0009503836,0.0002814724,0.0006594235,0.0000737588,0.0008005931,0.00170732,0.9925502,0.00004707529,0.0000758087,0.0005425529],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928821,0.003954856,0.0004236946,0.0001303988,0.00002277118,0.0002299664,0.0001549575,0.00004562222,0.002155662],"genre_scores_gemma":[0.9987732,0.0003349688,0.0005752976,0.0000621995,0.00003750783,0.00004512423,0.00003209726,0.00008192963,0.00005768739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005891116,"threshold_uncertainty_score":0.9997225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01398432813207677,"score_gpt":0.245338624376,"score_spread":0.2313542962439232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}