{"id":"W1980007697","doi":"10.3390/metabo4030807","title":"Metabolic Effects of Known and Novel HDAC and SIRT Inhibitors in Glioblastomas Independently or Combined with Temozolomide","year":2014,"lang":"en","type":"article","venue":"Metabolites","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Atlantic Cancer Research Institute; Université de Moncton; National Research Council Canada","funders":"Brain Tumour Foundation of Canada; Fondation de la recherche en santé du Nouveau-Brunswick; Université de Moncton; New Brunswick Innovation Foundation; Beatrice Hunter Cancer Research Institute; Cancer Research Institute","keywords":"Temozolomide; Histone deacetylase; Acetylation; Histone deacetylase inhibitor; Pharmacology; Cancer research; Nicotinamide phosphoribosyltransferase; Chemistry; Biochemistry; Enzyme; Biology; NAD+ kinase; Histone; Glioblastoma; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004279298,0.0002376307,0.0004567954,0.0002264072,0.0000515015,0.00002759914,0.0001364566,0.000160707,0.000004576741],"category_scores_gemma":[0.0005778004,0.00017641,0.00004215753,0.0002837406,0.0003001067,0.00001258238,0.0001860948,0.0001616377,0.000002142932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007229898,"about_ca_system_score_gemma":0.00007429578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001224999,"about_ca_topic_score_gemma":0.0004228912,"domain_scores_codex":[0.9985094,0.0001574498,0.0002949735,0.0004522127,0.0002524853,0.0003334939],"domain_scores_gemma":[0.9992011,0.0001320776,0.0001026698,0.0003217021,0.00009549019,0.0001470074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000635693,0.0001582282,0.01383879,0.0001544848,0.00006413825,0.000005761971,0.0001195804,0.000005414734,0.981519,0.0004986506,0.00008455764,0.002915668],"study_design_scores_gemma":[0.003129627,0.0008827677,0.0262071,0.00006022853,0.0000402759,0.00002771664,0.00003722159,0.00006051128,0.9574462,0.00003176182,0.01185434,0.0002222296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943095,0.004792884,0.0001743499,0.00005038365,0.00006827543,0.0003786842,0.00001144616,0.00001127483,0.0002032399],"genre_scores_gemma":[0.9981717,0.0002681933,0.0008715934,0.00005312109,0.00011031,0.00003551451,0.00001517088,0.00003562919,0.0004387363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02407282,"threshold_uncertainty_score":0.719379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004864825476100741,"score_gpt":0.2315896706629061,"score_spread":0.2267248451868054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}