{"id":"W1980007697","doi":"10.3390/metabo4030807","title":"Metabolic Effects of Known and Novel HDAC and SIRT Inhibitors in Glioblastomas Independently or Combined with Temozolomide","year":2014,"lang":"en","type":"article","venue":"Metabolites","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Atlantic Cancer Research Institute; Université de Moncton; National Research Council Canada","funders":"Brain Tumour Foundation of Canada; Fondation de la recherche en santé du Nouveau-Brunswick; Université de Moncton; New Brunswick Innovation Foundation; Beatrice Hunter Cancer Research Institute; Cancer Research Institute","keywords":"Temozolomide; Histone deacetylase; Acetylation; Histone deacetylase inhibitor; Pharmacology; Cancer research; Nicotinamide phosphoribosyltransferase; Chemistry; Biochemistry; Enzyme; Biology; NAD+ kinase; Histone; Glioblastoma; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002534965,0.000332338,0.0007351825,0.0003524739,0.0001738093,0.0002840025,0.0002415596,0.0001944207,0.0007803686],"category_scores_gemma":[0.0001744483,0.0001299636,0.0003945036,0.0003116255,0.0001835331,0.0002275355,0.0001529896,0.000391501,0.0001247906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003856108,"about_ca_system_score_gemma":0.0003007818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001903704,"about_ca_topic_score_gemma":0.008097436,"domain_scores_codex":[0.9998688,0.00003073601,0.00001424298,0.0000197285,0.00002650295,0.00004011501],"domain_scores_gemma":[0.9999192,0.00001495374,0.00001526099,0.000008727068,0.00001242525,0.00002948176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005324866,0.0006410668,0.001699399,0.0002172927,0.000157606,0.0001282161,0.00006518378,0.0004400365,0.9759413,0.00008616142,0.0002431545,0.01505575],"study_design_scores_gemma":[0.0003502026,0.009894011,0.02676984,0.00001922068,0.0004398516,0.0002503074,0.0001087038,0.001592212,0.9566779,0.00004613326,0.003832721,0.00001883993],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952651,0.003623887,0.0002522756,0.00005629702,0.00004296093,0.00001641775,0.0002338178,0.0000239109,0.000485325],"genre_scores_gemma":[0.9936035,0.003844725,0.001052975,0.00004518358,0.00002739362,0.00003329087,0.0005904326,0.00001606003,0.0007863885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001903704,"threshold_uncertainty_score":0.003785253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004864825476100741,"score_gpt":0.2315896706629061,"score_spread":0.2267248451868054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}