{"id":"W1980029336","doi":"10.1111/j.1471-4159.2007.04689.x","title":"Oxysterols, cholesterol homeostasis, and Alzheimer disease","year":2007,"lang":"en","type":"review","venue":"Journal of Neurochemistry","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":177,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Oxysterol; Liver X receptor; ABCA1; Cholesterol; Neurodegeneration; Amyloid precursor protein; Apolipoprotein E; Chemistry; Cholesterol 7 alpha-hydroxylase; Nuclear receptor; Biology; Neuroprotection; Biochemistry; Alzheimer's disease; Cell biology; Internal medicine; Pharmacology; Transporter; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003118405,0.0005150518,0.002208001,0.0002392897,0.0000407737,0.00006260313,0.0002515707,0.0003111946,0.00003272724],"category_scores_gemma":[0.0001625278,0.0003725576,0.0008063964,0.0001808791,0.000099638,0.0001025873,0.00009928875,0.001309806,0.00001135382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003670456,"about_ca_system_score_gemma":0.0003727565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":4.27674e-7,"about_ca_topic_score_gemma":5.468147e-8,"domain_scores_codex":[0.9974832,0.00005941814,0.001242816,0.0003400763,0.0005508533,0.0003236384],"domain_scores_gemma":[0.9971277,0.0001104752,0.001130505,0.0004677666,0.0001829662,0.000980627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001055386,0.000162063,0.00004490103,0.0146598,0.0003691604,0.0009973642,0.00001653866,3.048843e-8,0.00008239238,5.911081e-7,0.001679991,0.9818816],"study_design_scores_gemma":[0.001006167,0.00008171125,0.001832405,0.01353746,0.00727591,0.008521119,0.000007780863,2.289619e-7,0.00001792782,0.000002075594,0.9674813,0.0002359835],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002008235,0.9968337,0.000005566211,0.0001312785,0.000498921,0.0002485182,0.00003084384,0.00001560568,0.0002273354],"genre_scores_gemma":[0.0004215552,0.9959416,0.00007013196,0.00055916,0.002606047,0.000004420737,0.00002397438,0.00008534757,0.0002877083],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9816456,"threshold_uncertainty_score":0.9998726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08250783481910132,"score_gpt":0.3713653278152181,"score_spread":0.2888574929961168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}