{"id":"W1980052515","doi":"10.1016/j.jsbmb.2005.01.011","title":"Inhibition of human-type 1 3β-hydroxysteroid deshydrogenase/Δ5-Δ4-isomerase expression using siRNA","year":2005,"lang":"en","type":"article","venue":"The Journal of Steroid Biochemistry and Molecular Biology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Wilfrid Laurier University; Université Laval","funders":"F. Hoffmann-La Roche","keywords":"Transfection; HEK 293 cells; RNA; RNA interference; Biology; Enzyme; Small interfering RNA; DNA; Messenger RNA; Molecular biology; Biochemistry; Chemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003211912,0.0007086283,0.0005351425,0.0003444745,0.0003407354,0.0004922234,0.0004015312,0.0003695147,0.003029641],"category_scores_gemma":[0.0001688605,0.000264618,0.00061773,0.0003121215,0.0003902434,0.0002278892,0.0002128263,0.00100509,0.001163986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006644381,"about_ca_system_score_gemma":0.0005790452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001983988,"about_ca_topic_score_gemma":0.003339165,"domain_scores_codex":[0.9996462,0.00004102656,0.00004797525,0.000103872,0.00007481678,0.00008605907],"domain_scores_gemma":[0.999851,0.00005122503,0.00002343165,0.0000252065,0.00002444894,0.0000246082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001189284,0.00002111899,0.00005717806,0.00005049022,0.00001119501,0.00003237735,0.00002196966,0.0000446275,0.9981509,0.0002655787,0.0001512298,0.001074527],"study_design_scores_gemma":[0.00001142379,0.00004033845,0.0002736179,0.000001310993,0.00001091381,0.00004024158,0.000008759333,0.0002778494,0.9972017,0.00001783616,0.00211433,0.00000179947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.942597,0.004573183,0.03352588,0.0009827148,0.0006054657,0.0002513014,0.004185475,0.001159961,0.01211903],"genre_scores_gemma":[0.9584169,0.002136091,0.01504556,0.0002808986,0.0000499079,0.0002574914,0.00468304,0.0002090904,0.01892096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003029641,"threshold_uncertainty_score":0.01013517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01411535209864105,"score_gpt":0.2835634465908791,"score_spread":0.2694480944922381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}