{"id":"W1980104349","doi":"10.1074/jbc.m113.488650","title":"The Prion Protein Modulates A-type K+ Currents Mediated by Kv4.2 Complexes through Dipeptidyl Aminopeptidase-like Protein 6","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; University of British Columbia; Occupational Cancer Research Centre; University of Toronto; University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Cell biology; Cholinergic; Aminopeptidase; Mutant; Chemistry; Biophysics; Biology; In vivo; Wild type; Biochemistry; Neuroscience; Amino acid; Gene; Genetics; Leucine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001558294,0.0002955962,0.0001749936,0.0001176811,0.00009788681,0.0002313482,0.0001848283,0.0002303389,0.0004733857],"category_scores_gemma":[0.0001788122,0.0001082278,0.0002163059,0.00006641532,0.000213139,0.000244054,0.000147972,0.0004445674,0.0001591474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001740342,"about_ca_system_score_gemma":0.00007849191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002525262,"about_ca_topic_score_gemma":0.0002372672,"domain_scores_codex":[0.9998865,0.00003857237,0.00001391804,0.00001632655,0.00001833177,0.00002622337],"domain_scores_gemma":[0.9999183,0.00001278519,0.00002662082,0.000007121176,0.00001064015,0.0000245721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002117777,0.00002398338,0.0001268316,0.00002548564,0.00000563859,0.00007247965,0.00001215547,0.00003154583,0.9990258,0.00003810161,0.00002067347,0.0004055279],"study_design_scores_gemma":[0.00013773,0.001356506,0.01474953,0.00001297303,0.00005424913,0.0007070547,0.00006482426,0.002344926,0.9791058,0.0001756008,0.001278663,0.00001218409],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985816,0.0005329837,0.0004567969,0.00004140863,0.0000123704,0.000009831406,0.00004024761,0.0000224324,0.0003023235],"genre_scores_gemma":[0.9984546,0.0004546783,0.0005137192,0.00004238032,0.000008511282,0.00001233472,0.00005883116,0.000007228848,0.0004477859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004733857,"threshold_uncertainty_score":0.001583636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01757103361680021,"score_gpt":0.255402627151482,"score_spread":0.2378315935346818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}