{"id":"W1980118603","doi":"10.1182/blood-2011-07-367532","title":"Caspase-8 is essential for maintaining chromosomal stability and suppressing B-cell lymphomagenesis","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Tech University; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Queen's University; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"Necroptosis; Cytokinesis; Caspase 8; Cancer research; Biology; NLRP1; Caspase; B cell; Apoptosis; Immune system; Caspase 2; Caspase 1; Caspase 3; Function (biology); Programmed cell death; Cell; Immunology; Cell biology; Genetics; Cell division; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001343503,0.0003502941,0.0002312128,0.0003954796,0.0001742209,0.0004409937,0.0002849607,0.0002946671,0.001039685],"category_scores_gemma":[0.0003223222,0.000128205,0.0001617053,0.0001737935,0.0002603708,0.0003026062,0.0002915462,0.000433201,0.0006169528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002736296,"about_ca_system_score_gemma":0.0001888293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000180854,"about_ca_topic_score_gemma":0.0001589017,"domain_scores_codex":[0.9998086,0.00003900555,0.00002252513,0.00003648255,0.00005085823,0.00004251707],"domain_scores_gemma":[0.9997289,0.0000283571,0.0001076789,0.00003755084,0.00003828682,0.00005917877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001112493,0.00001716868,0.0006325506,0.0000321338,0.000004927121,0.0001378053,0.000007739994,0.00005900939,0.9960653,0.0001711053,0.000039198,0.002721886],"study_design_scores_gemma":[0.00004497606,0.0003421175,0.008518477,0.00001063672,0.00001723194,0.002282928,0.00002896944,0.0008073435,0.983003,0.0004843454,0.004454002,0.000006054588],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987117,0.004798301,0.005373588,0.0001994012,0.00003070915,0.00001519459,0.0003326436,0.0002461001,0.001887125],"genre_scores_gemma":[0.9953474,0.0008357953,0.002447641,0.00001604099,0.0000114362,0.00001079592,0.0002411592,0.00001695265,0.001072703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001039685,"threshold_uncertainty_score":0.00347811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.010467292999096,"score_gpt":0.2303387075404314,"score_spread":0.2198714145413354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}