{"id":"W1980135244","doi":"10.1016/j.chembiol.2015.01.003","title":"Global Analysis of Protein N-Myristoylation and Exploration of N-Myristoyltransferase as a Drug Target in the Neglected Human Pathogen Leishmania donovani","year":2015,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Engineering and Physical Sciences Research Council; McMaster University; European Commission; British Heart Foundation; Wellcome Trust; Medical Research Council; Directorate for Biological Sciences","keywords":"Myristoylation; Leishmania; Biology; Leishmania donovani; Myristic acid; Amastigote; Biochemistry; Proteomics; Cell biology; Human pathogen; Lipid-anchored protein; Leishmaniasis; Visceral leishmaniasis; Autophagy; Fatty acid; Phosphorylation; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001203102,0.0002364564,0.0001913873,0.0002117702,0.00009308316,0.0001685523,0.0001048557,0.0001568487,0.0005241525],"category_scores_gemma":[0.00008440796,0.0000873656,0.000188007,0.0001900275,0.0001633552,0.0001792651,0.0001766612,0.0003054834,0.0001257767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001737935,"about_ca_system_score_gemma":0.0001238938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003648533,"about_ca_topic_score_gemma":0.0005930727,"domain_scores_codex":[0.9999497,0.000006041825,0.000002554208,0.00001524833,0.0000139888,0.00001261414],"domain_scores_gemma":[0.9999539,0.000007605022,0.00001380095,0.000005038506,0.0000117592,0.000007858878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005754797,0.000004690901,0.0003403965,0.00002583366,0.000004477101,0.00001318443,0.000007055731,0.0000890628,0.9987108,0.00004907691,0.00001305673,0.0006848495],"study_design_scores_gemma":[0.000005017684,0.0001844555,0.008819052,0.000003235816,0.00002102535,0.0001140116,0.00003358005,0.001541467,0.988316,0.0000732211,0.0008844255,0.000004526865],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919724,0.0008616474,0.005665507,0.00006137636,0.000005784266,0.00001769869,0.0005046676,0.00005970215,0.0008511257],"genre_scores_gemma":[0.994105,0.0008624524,0.003433923,0.00004772101,0.000002980246,0.00002230387,0.0005651636,0.00001616578,0.0009442936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005241525,"threshold_uncertainty_score":0.001753509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04052821978949403,"score_gpt":0.3357161460267185,"score_spread":0.2951879262372245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}