{"id":"W1980157378","doi":"10.1159/000136433","title":"The in vivo Antibradykinin Activity of Seclazone (7-Chloro-3,3a-Dihydro-2H,9H-Isoxazolo[3,2-b] [1,3]Benzoxazin-9-One), a New Anti-Inflammatory Agent","year":2008,"lang":"en","type":"article","venue":"Pharmacology","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Bradykinin; Histamine; In vivo; Chemistry; Pharmacology; Guinea pig; Intradermal injection; Vascular permeability; Diuretic; Endocrinology; Medicine; Biochemistry; Immunology; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004661698,0.0003639161,0.0007651441,0.0002375236,0.0003958814,0.000008566715,0.0005864754,0.000384587,0.00331085],"category_scores_gemma":[0.00004032614,0.0003118919,0.0001888467,0.0003234437,0.0009018265,0.0001338928,0.0002624442,0.0007320878,0.0003245513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009652868,"about_ca_system_score_gemma":0.0003337235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000625865,"about_ca_topic_score_gemma":0.0003970881,"domain_scores_codex":[0.9973156,0.0004830975,0.0006864904,0.0005422928,0.00009611958,0.0008763489],"domain_scores_gemma":[0.9985696,0.000446512,0.0004027635,0.0004202804,0.00007051296,0.00009033753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006980947,0.0005709841,0.007247215,0.00005130744,0.0002889371,0.0001056464,0.0009940247,0.00004245259,0.9537647,0.0004245407,0.03330788,0.00250419],"study_design_scores_gemma":[0.00422876,0.000238225,0.02988275,0.00001902641,0.00008607077,0.0001536771,0.00004669833,0.00005137389,0.7255809,0.00006849693,0.2393226,0.0003214395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886767,0.004488706,0.00006210714,0.001119951,0.0021237,0.0005706669,0.00003864026,0.00008457342,0.002834972],"genre_scores_gemma":[0.9895023,0.003081694,0.00004527151,0.0003225327,0.0001774689,0.00003673429,0.00001752976,0.00003975481,0.006776716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2281839,"threshold_uncertainty_score":0.9999333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02230145222671534,"score_gpt":0.2551595657187635,"score_spread":0.2328581134920482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}