{"id":"W1980163680","doi":"10.1002/prot.21942","title":"Protein kinase C isozymes and their selectivity towards ruboxistaurin","year":2008,"lang":"en","type":"article","venue":"Proteins Structure Function and Bioinformatics","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Ontario Innovation Trust; Eli Lilly and Company; Pension Real Estate Association","keywords":"Protein kinase C; Isozyme; Binding site; Chemistry; Enzyme; Biochemistry; Ligand (biochemistry); Binding selectivity; Active site; Biology; Biophysics; Stereochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000160055,0.0002420756,0.000245746,0.0001313876,0.0001495231,0.0003390248,0.0002521764,0.0002487738,0.0008729388],"category_scores_gemma":[0.0003016416,0.0001167248,0.0001789223,0.000118558,0.0002546138,0.0001945646,0.0001272694,0.000384544,0.0002580876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003417885,"about_ca_system_score_gemma":0.0002324387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001031118,"about_ca_topic_score_gemma":0.0009952722,"domain_scores_codex":[0.9998672,0.00002198852,0.000004486742,0.00003007389,0.00005133408,0.00002483727],"domain_scores_gemma":[0.9998865,0.00003976628,0.00003243606,0.000006280812,0.00001861896,0.00001643773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002666924,0.00003913711,0.001898239,0.00006942683,0.00001816082,0.0001264038,0.00002163469,0.01409245,0.974353,0.002484754,0.0001011079,0.006529093],"study_design_scores_gemma":[0.00006279352,0.0002004472,0.007888468,0.000008916069,0.00003561798,0.0006082933,0.00004282477,0.06599917,0.9193076,0.003070638,0.002752024,0.00002314653],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850324,0.001924331,0.009560216,0.0001614306,0.00001249918,0.0000157443,0.00007037386,0.00005375576,0.003169292],"genre_scores_gemma":[0.9968208,0.0005097308,0.002161623,0.00002892333,0.000002621365,0.000006660942,0.00006111838,0.000007001302,0.0004015241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001031118,"threshold_uncertainty_score":0.00292027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008839193803808564,"score_gpt":0.2006112974065406,"score_spread":0.1917721036027321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}