{"id":"W1980163680","doi":"10.1002/prot.21942","title":"Protein kinase C isozymes and their selectivity towards ruboxistaurin","year":2008,"lang":"en","type":"article","venue":"Proteins Structure Function and Bioinformatics","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Ontario Innovation Trust; Eli Lilly and Company; Pension Real Estate Association","keywords":"Protein kinase C; Isozyme; Binding site; Chemistry; Enzyme; Biochemistry; Ligand (biochemistry); Binding selectivity; Active site; Biology; Biophysics; Stereochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001055886,0.0002473542,0.0001776438,0.00007946956,0.0003459401,0.00004992935,0.00006268902,0.0001978522,0.00002845467],"category_scores_gemma":[0.0000646241,0.0001868821,0.0000510663,0.0001266501,0.000166803,0.00002669725,0.00009781653,0.0001491751,0.000001681875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001344118,"about_ca_system_score_gemma":0.00008485351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001676717,"about_ca_topic_score_gemma":0.00001882625,"domain_scores_codex":[0.9991083,0.00004084742,0.0002521259,0.0002356996,0.000137286,0.0002257192],"domain_scores_gemma":[0.9994308,0.000003628746,0.0001285445,0.0002100785,0.00009476589,0.0001321823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003257862,0.00004822566,0.001095902,0.000304305,0.00007917925,0.000002538641,0.0004504292,0.00002000947,0.9212674,0.0008337878,0.0002729449,0.07529952],"study_design_scores_gemma":[0.00151988,0.0008116911,0.008480017,0.00005493791,0.0000212518,0.0002974638,0.0002573669,0.003288389,0.9585576,0.001575292,0.02454226,0.0005938247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9555624,0.0007360489,0.04216401,0.0001471554,0.00006369873,0.000809059,0.00005310608,0.0000539535,0.0004105442],"genre_scores_gemma":[0.9903635,0.00008350533,0.008766196,0.0002372313,0.0001507001,0.00003871239,0.00009566483,0.0000164708,0.0002480355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07470571,"threshold_uncertainty_score":0.7620832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008839193803808564,"score_gpt":0.2006112974065406,"score_spread":0.1917721036027321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}