{"id":"W1980224065","doi":"10.1038/cdd.2009.148","title":"Disruption of PPARγ signaling results in mouse prostatic intraepithelial neoplasia involving active autophagy","year":2009,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"DOD Prostate Cancer Research Program; Institute of Genetics; Vanderbilt University; National Eye Institute; National Cancer Institute; National Institutes of Health; Vanderbilt University Medical Center; National Institute of Diabetes and Digestive and Kidney Diseases; U.S. Department of Defense","keywords":"Autophagy; Cancer research; Intraepithelial neoplasia; Signal transduction; Biology; Peroxisome proliferator-activated receptor; Cell biology; Medicine; Apoptosis; Internal medicine; Receptor; Prostate; Genetics; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008048607,0.0001249636,0.0001348469,0.00008185046,0.00004130501,0.00002054217,0.00005077826,0.0001312116,0.000003595413],"category_scores_gemma":[0.00006909262,0.000117795,0.00003142557,0.00006948509,0.00001870973,0.00001500572,0.00002045834,0.00008514369,8.400829e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002326267,"about_ca_system_score_gemma":0.00003233524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001329055,"about_ca_topic_score_gemma":0.000009302355,"domain_scores_codex":[0.9991868,0.00006424421,0.0002508569,0.000248439,0.00009082245,0.0001588079],"domain_scores_gemma":[0.9996372,0.00001335694,0.0001403132,0.0001082614,0.00004573189,0.00005514531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004054418,0.0001203431,0.004083028,0.00002788226,0.000008328931,5.263524e-7,0.0004122336,0.00006711285,0.9915476,0.00002976937,0.000006490186,0.003291188],"study_design_scores_gemma":[0.001140317,0.0002777317,0.03453262,0.00002280535,0.0000104924,9.930732e-7,0.00008847771,0.0008817966,0.9627345,0.0001813147,0.00001332777,0.0001156556],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987607,0.0002238864,0.0005875666,0.00001913274,0.00005506341,0.0002042479,0.00002657069,0.00001039314,0.0001124185],"genre_scores_gemma":[0.9990525,0.0002324708,0.0002388601,0.00002822204,0.00005837879,0.000008473845,0.0003040856,0.000009112655,0.00006792483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03044959,"threshold_uncertainty_score":0.4803541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00785342145956573,"score_gpt":0.2289229578995864,"score_spread":0.2210695364400206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}