{"id":"W1980244314","doi":"10.1021/bi011727i","title":"A Structural View of the Action of<i>Escherichia coli</i>(<i>lac</i>Z) β-Galactosidase<sup>,</sup>","year":2001,"lang":"en","type":"article","venue":"Biochemistry","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":230,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences","keywords":"Moiety; Chemistry; Nucleophile; Stereochemistry; Active site; Binding site; Substrate (aquarium); Escherichia coli; lac operon; Catalysis; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000112087,0.0003331614,0.000431621,0.00001704518,0.0001107845,0.0000231187,0.0005985199,0.0003565621,0.001652216],"category_scores_gemma":[0.0001867481,0.000271819,0.0003955833,0.0003571749,0.0002925598,0.00007360402,0.0001412487,0.0003318849,0.00000539682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009537105,"about_ca_system_score_gemma":0.0001562122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006486593,"about_ca_topic_score_gemma":0.000001967801,"domain_scores_codex":[0.9982458,0.00002589243,0.0005744786,0.0004074513,0.0004042032,0.0003421376],"domain_scores_gemma":[0.9982304,0.0001142216,0.0003997385,0.0009905513,0.0001389757,0.000126128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001009966,0.00007275167,0.00396252,0.0008919224,0.00008547893,0.000004037759,0.0001119166,0.00004212337,0.9932398,0.00000756776,0.000409721,0.00107116],"study_design_scores_gemma":[0.0004025699,0.000006190678,0.0003068827,0.0002385383,0.00009828457,0.00004122172,0.0004000602,0.0005284829,0.9947453,0.00005302856,0.002902796,0.0002767002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830872,0.0004905919,0.000006536544,0.0001757577,0.00006012759,0.0000688784,0.0001071449,0.00005724703,0.01594653],"genre_scores_gemma":[0.9968353,0.000118585,0.00006871322,0.00005195416,0.0002592223,0.00001975098,0.00003845754,0.00003497758,0.002573045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01374811,"threshold_uncertainty_score":0.9999734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01742836770607618,"score_gpt":0.234519761545504,"score_spread":0.2170913938394278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}