{"id":"W1980246650","doi":"10.1074/jbc.m109383200","title":"Pnk1, a DNA Kinase/Phosphatase Required for Normal Response to DNA Damage by γ-Radiation or Camptothecin inSchizosaccharomyces pombe","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Calgary","funders":"","keywords":"DNA-PKcs; DNA damage; Camptothecin; DNA; Phosphatase; Kinase; Chemistry; Biochemistry; Biology; Molecular biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007121723,0.0006236712,0.0003438804,0.0002031754,0.0002626119,0.0003717157,0.0001708295,0.0002434489,0.0008283873],"category_scores_gemma":[0.000142718,0.0001589361,0.0001973695,0.0001591712,0.000257552,0.0002726262,0.0002053132,0.000407651,0.0006068005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006312684,"about_ca_system_score_gemma":0.0003670998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001177963,"about_ca_topic_score_gemma":0.00184311,"domain_scores_codex":[0.9999319,0.000004839254,0.000005321251,0.00002248833,0.00002045723,0.00001485461],"domain_scores_gemma":[0.9999107,0.00001044166,0.0000261631,0.00001054867,0.00001047122,0.00003173086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001004278,0.00001189304,0.0004768413,0.0000678846,0.000003033684,0.0001178299,0.00001602537,0.0001086647,0.9973264,0.0001132809,0.00004020173,0.001617416],"study_design_scores_gemma":[0.00001402158,0.00008675444,0.008318313,0.000008129112,0.00001308641,0.0008693483,0.00002996247,0.0007627227,0.9843524,0.0001135092,0.005423956,0.000007863414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874058,0.004618984,0.004889983,0.000154666,0.00004339166,0.00004774686,0.001514112,0.0001938613,0.001131282],"genre_scores_gemma":[0.9827771,0.003167066,0.005793733,0.00005059317,0.0000134154,0.0000406564,0.004792108,0.00006410585,0.003301054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001177963,"threshold_uncertainty_score":0.0045802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02548231951259618,"score_gpt":0.2707468545644073,"score_spread":0.2452645350518111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}