{"id":"W1980296375","doi":"10.1182/blood-2011-01-329656","title":"A CCR4 antagonist combined with vaccines induces antigen-specific CD8+ T cells and tumor immunity against self antigens","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":157,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Labex Immuno-Oncology; Institut National Du Cancer; Université Pierre et Marie Curie; Université Paris Descartes; Ligue Contre le Cancer; Agence Nationale de la Recherche; Association pour la Recherche sur le Cancer","keywords":"CCR4; Immunology; Antigen; FOXP3; Population; CD8; Cytotoxic T cell; CCL17; Immune tolerance; Cancer research; Biology; Immune system; Medicine; Chemokine; Chemokine receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000201153,0.0004241499,0.0005709253,0.0001700372,0.0005933932,0.00003952992,0.0004286814,0.0003038452,0.0003052982],"category_scores_gemma":[0.000008024842,0.0003321116,0.00008416986,0.0002344516,0.0004476587,0.0001404874,0.0002122553,0.0005476361,0.0003841559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001170509,"about_ca_system_score_gemma":0.00008033214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001998839,"about_ca_topic_score_gemma":0.00005533378,"domain_scores_codex":[0.9980939,0.0002554859,0.0004054773,0.0005363362,0.00004407968,0.0006647169],"domain_scores_gemma":[0.9989108,0.00008294945,0.0002276791,0.0006113258,0.0001137994,0.00005341355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003997358,0.002101078,0.0157975,0.00002471783,0.0005474612,0.0001150968,0.001739119,5.714534e-8,0.9783283,0.0002197276,0.0004025371,0.0003246204],"study_design_scores_gemma":[0.006286604,0.00123547,0.02451225,0.0000403641,0.00009507375,0.0003666721,0.0008588557,2.539925e-7,0.9504547,0.00005019854,0.01561948,0.0004800982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892371,0.005954322,0.000006432499,0.00004261087,0.0005644493,0.0003838463,0.00004195835,0.0002631904,0.003506126],"genre_scores_gemma":[0.9957865,0.002951092,0.0004257676,0.0001406324,0.0000379965,0.00002082826,0.0000865211,0.00004610245,0.0005045531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02787367,"threshold_uncertainty_score":0.9999131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0145206428073635,"score_gpt":0.193934427001518,"score_spread":0.1794137841941545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}