{"id":"W1980305749","doi":"10.1073/pnas.1106291108","title":"PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":414,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research","keywords":"PINK1; Oxidative stress; Mitochondrion; PTEN; Biology; Internal medicine; Reactive oxygen species; Endocrinology; Mitophagy; Cell biology; Cardiac function curve; Oxidative phosphorylation; Cardiomyopathy; Autophagy; Medicine; Apoptosis; Signal transduction; Heart failure; Biochemistry; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005975738,0.00009520524,0.0001663392,0.0001526437,0.0001999254,0.00001064646,0.0002119526,0.00007540415,0.0001149033],"category_scores_gemma":[0.0001420092,0.00006228601,0.0001191979,0.0004122441,0.0002312126,0.0003607724,0.00005271502,0.00008082645,0.000006650533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003275144,"about_ca_system_score_gemma":0.00005895907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001540712,"about_ca_topic_score_gemma":6.201091e-8,"domain_scores_codex":[0.9986309,0.000002298389,0.0002194172,0.0002533277,0.0007164549,0.0001776304],"domain_scores_gemma":[0.9993882,0.00002560514,0.0002231088,0.00001082089,0.0002795962,0.00007262696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001635528,0.001846081,0.2169595,0.0007195216,0.000391805,1.078311e-7,0.001194966,0.000009197866,0.6142513,0.1328342,0.02699418,0.003163639],"study_design_scores_gemma":[0.0009066112,0.0003681621,0.3381708,0.0001132532,0.0001162454,0.00001228001,0.0001627156,0.0003398721,0.606568,0.04979676,0.003360002,0.00008526038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840151,0.0001187189,0.000005431764,0.001528392,0.00004263038,0.0004507085,0.00003848177,0.000015041,0.0137855],"genre_scores_gemma":[0.9950162,0.00000995713,0.003379097,0.0008578138,0.00006894972,0.00003841572,5.156767e-7,0.000005366282,0.0006236461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1212113,"threshold_uncertainty_score":0.253995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09740730959470101,"score_gpt":0.3190976699305865,"score_spread":0.2216903603358855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}