{"id":"W1980328024","doi":"10.1016/j.brainres.2003.12.057","title":"Increased clusterin expression in old but not young adult S100B transgenic mice: evidence of neuropathological aging in a model of Down Syndrome","year":2004,"lang":"en","type":"article","venue":"Brain Research","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Clusterin; Genetically modified mouse; Biology; Synaptogenesis; Transgene; Senescence; Neurotrophin; Apoptosis; Pathological; Neuroscience; Microglia; Cell biology; Pathology; Gene; Immunology; Medicine; Genetics; Receptor; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001701895,0.000552599,0.0003806616,0.001164886,0.0002940586,0.0003929757,0.0003337055,0.0005964368,0.00166187],"category_scores_gemma":[0.0001839555,0.0003861124,0.0002188261,0.0003287575,0.000555928,0.0004935175,0.0003061937,0.0008661865,0.0003405668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003773042,"about_ca_system_score_gemma":0.0002167424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001847029,"about_ca_topic_score_gemma":0.002611934,"domain_scores_codex":[0.9998721,0.000009944091,0.00001503085,0.00003802926,0.00003311402,0.00003179488],"domain_scores_gemma":[0.9995067,0.00004091332,0.0001422964,0.00003002362,0.00004608368,0.0002339635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002010206,0.00001601026,0.0003445542,0.00001300766,0.000005956494,0.0001410393,0.00002703967,0.00001012399,0.9988012,0.00005581689,0.00003220597,0.0003520321],"study_design_scores_gemma":[0.00004970692,0.0003911539,0.05768112,0.00001475251,0.00006968096,0.002277144,0.0001967995,0.0006588744,0.9364259,0.0002546188,0.00196281,0.00001750855],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956467,0.0008781871,0.001848255,0.0001149461,0.00004292571,0.000008882338,0.0007226364,0.00008800042,0.0006494406],"genre_scores_gemma":[0.9876868,0.001184493,0.002787611,0.00008540707,0.00002107254,0.00004112644,0.0009032532,0.0001251446,0.007165069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001847029,"threshold_uncertainty_score":0.005559504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1189431876181072,"score_gpt":0.4035409228759265,"score_spread":0.2845977352578194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}