{"id":"W1980337003","doi":"10.1016/j.cell.2008.04.042","title":"BAP31 Interacts with Sec61 Translocons and Promotes Retrotranslocation of CFTRΔF508 via the Derlin-1 Complex","year":2008,"lang":"en","type":"article","venue":"Cell","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":165,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Cystic Fibrosis Foundation","keywords":"Endoplasmic reticulum; Biology; Translocon; Endoplasmic-reticulum-associated protein degradation; Sec61; Cell biology; Integral membrane protein; Cytoplasm; Membrane protein; ΔF508; Transport protein; Proteasome; Population; Mutant; Biochemistry; Membrane; Unfolded protein response; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003276461,0.0002845763,0.0003922993,0.0003286673,0.0005341814,0.0006674353,0.0003573741,0.0006005215,0.003211428],"category_scores_gemma":[0.0004331919,0.0003834731,0.0002658985,0.0002204623,0.0002820093,0.0004119376,0.0004810626,0.0007612322,0.001806036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007763311,"about_ca_system_score_gemma":0.0002184869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004794119,"about_ca_topic_score_gemma":0.0008244637,"domain_scores_codex":[0.9995986,0.00008591508,0.00003233327,0.00007257883,0.0001096636,0.0001010236],"domain_scores_gemma":[0.9996418,0.00009115183,0.00005318497,0.00006298735,0.00003958962,0.0001113537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002346336,0.00003921091,0.00014503,0.00003004725,0.000005457992,0.0001152604,0.00001502409,0.00003336357,0.9986672,0.0001072963,0.0001354774,0.0004719277],"study_design_scores_gemma":[0.00007176423,0.0001087062,0.006079297,0.000008439793,0.000008890544,0.0006656926,0.00005368407,0.001223964,0.9874806,0.0001098998,0.004177592,0.00001143885],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954339,0.001589316,0.0007953697,0.0003477799,0.00006873927,0.00002125737,0.0002488396,0.00007053123,0.001424202],"genre_scores_gemma":[0.9937738,0.0005630433,0.00105688,0.0001100777,0.00001819444,0.00002541661,0.0008069982,0.0000484406,0.003597145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003211428,"threshold_uncertainty_score":0.01074332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01148684794169727,"score_gpt":0.2152867951013345,"score_spread":0.2037999471596372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}