{"id":"W1980337003","doi":"10.1016/j.cell.2008.04.042","title":"BAP31 Interacts with Sec61 Translocons and Promotes Retrotranslocation of CFTRΔF508 via the Derlin-1 Complex","year":2008,"lang":"en","type":"article","venue":"Cell","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":165,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Cystic Fibrosis Foundation","keywords":"Endoplasmic reticulum; Biology; Translocon; Endoplasmic-reticulum-associated protein degradation; Sec61; Cell biology; Integral membrane protein; Cytoplasm; Membrane protein; ΔF508; Transport protein; Proteasome; Population; Mutant; Biochemistry; Membrane; Unfolded protein response; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000323942,0.00009006329,0.00008689897,0.00001188453,0.00006764184,0.000005950929,0.00008017958,0.00004176971,0.00001648762],"category_scores_gemma":[0.000008437057,0.00005837569,0.00003458426,0.00003630281,0.000194087,0.000002714343,0.00001293011,0.00004720464,0.000001340279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001886575,"about_ca_system_score_gemma":0.00003777962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000244875,"about_ca_topic_score_gemma":0.00002452644,"domain_scores_codex":[0.9995252,0.00002921175,0.0001122133,0.0001593257,0.00006967854,0.0001043582],"domain_scores_gemma":[0.9996411,0.00001629012,0.00004809668,0.0001887949,0.00004988219,0.000055854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001292294,0.0001200341,0.008343291,0.00009287332,0.00002414126,0.000005565632,0.0004376988,0.00003808074,0.9896103,0.00001625156,0.0003740252,0.0008085288],"study_design_scores_gemma":[0.0008718219,0.0003189353,0.01429758,0.00002001072,0.00003691296,0.00006007839,0.0001012313,0.000389312,0.9820099,0.00002357038,0.00174299,0.0001275913],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937142,0.0005144271,0.003715124,0.0001714656,0.00001627306,0.0001939777,0.00001463355,0.000004860372,0.001655065],"genre_scores_gemma":[0.9990849,0.0001710878,0.0003845965,0.00009025873,0.00002866904,0.00001281501,0.00005867819,0.00001004816,0.0001589483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007600312,"threshold_uncertainty_score":0.2380491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01148684794169727,"score_gpt":0.2152867951013345,"score_spread":0.2037999471596372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}