{"id":"W1980385867","doi":"10.1074/jbc.m110.119107","title":"Binding of Anti-GRP78 Autoantibodies to Cell Surface GRP78 Increases Tissue Factor Procoagulant Activity via the Release of Calcium from Endoplasmic Reticulum Stores","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute; Hamilton General Hospital; St. Joseph’s Healthcare Hamilton; McMaster University; St. Joseph's Hospital","funders":"Canadian Institutes of Health Research; Amgen; McMaster University; Amgen Canada; National Institutes of Health; National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada","keywords":"Endoplasmic reticulum; Tissue factor; Glucose-regulated protein; Thapsigargin; Phosphatidylserine; Cell; Cytosol; Unfolded protein response; Cell culture; Cell biology; Cancer cell; Chemistry; Biology; Biochemistry; Internal medicine; Cancer; Medicine; Phospholipid; Coagulation; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001801369,0.0005170351,0.0005415956,0.0002637735,0.0001318495,0.0002485429,0.0002210386,0.0004498732,0.001618993],"category_scores_gemma":[0.0003008234,0.0001513141,0.0004315398,0.0001735705,0.0002223262,0.0001582384,0.0001861787,0.0008121746,0.0005600018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003209068,"about_ca_system_score_gemma":0.0001391353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004137819,"about_ca_topic_score_gemma":0.000469184,"domain_scores_codex":[0.9996287,0.00008003719,0.00002650791,0.0000663338,0.00008418076,0.0001143139],"domain_scores_gemma":[0.9998343,0.00004184976,0.00004121567,0.00002351834,0.00002092818,0.00003811652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001461803,0.00005713139,0.0002640907,0.00004317902,0.00001422613,0.00008950375,0.00001200567,0.00004081828,0.9977329,0.00001670554,0.00006196173,0.001521266],"study_design_scores_gemma":[0.00007162183,0.002819074,0.02050045,0.00001262481,0.00006134008,0.0016374,0.00004049243,0.001318091,0.9705094,0.0000611474,0.002959094,0.000009359514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937448,0.003202409,0.001788841,0.000132132,0.00006443864,0.00002778076,0.00009436541,0.00009234124,0.0008528891],"genre_scores_gemma":[0.9969035,0.0009453003,0.0009958409,0.000128661,0.00003216001,0.00002282138,0.0002144808,0.00001425023,0.0007430429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001618993,"threshold_uncertainty_score":0.005416036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01389067242436886,"score_gpt":0.2638105489839433,"score_spread":0.2499198765595745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}