{"id":"W1980397367","doi":"10.1111/micc.12161","title":"Pretreatment of Human Cerebrovascular Endothelial Cells with <scp>CO</scp>‐releasing Molecule‐3 Interferes with <scp>JNK</scp>/<scp>AP</scp>‐1 Signaling and Suppresses <scp>LPS</scp>‐induced Proadhesive Phenotype","year":2014,"lang":"en","type":"article","venue":"Microcirculation","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Lawson Health Research Institute","funders":"Heart and Stroke Foundation of Canada","keywords":"p38 mitogen-activated protein kinases; Phosphorylation; Chemistry; MAPK/ERK pathway; Western blot; Cell adhesion molecule; Cell biology; Signal transduction; Downregulation and upregulation; Stimulation; Molecular biology; Pharmacology; Biochemistry; Biology; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001578031,0.0003316951,0.0004241141,0.0001294696,0.000205296,0.0003366483,0.0002287236,0.0003733645,0.001706692],"category_scores_gemma":[0.0001581028,0.0001071553,0.0004453961,0.0001938846,0.0002591115,0.0001835401,0.0001832689,0.0006155013,0.0004647406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003014004,"about_ca_system_score_gemma":0.0003573096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001645215,"about_ca_topic_score_gemma":0.001989897,"domain_scores_codex":[0.999757,0.00003063707,0.00002396343,0.00005658843,0.00005459502,0.00007729811],"domain_scores_gemma":[0.9999186,0.00001352762,0.00001814119,0.00001568672,0.00001437689,0.00001960893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004177261,0.00007520829,0.0001775796,0.00008477826,0.00001723339,0.0001315866,0.0000206461,0.00006493471,0.9972608,0.00005728473,0.0001990655,0.00149307],"study_design_scores_gemma":[0.00006123324,0.0006064471,0.00552563,0.000009923607,0.0000414014,0.0004714183,0.00004428994,0.0006721524,0.9880345,0.00003119311,0.004493643,0.000007990697],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901463,0.003013908,0.00311907,0.000239544,0.0001466616,0.00007168673,0.001088082,0.00009508294,0.002079668],"genre_scores_gemma":[0.9910059,0.001453572,0.002989773,0.0001457019,0.00004251667,0.000140149,0.001850642,0.00001971319,0.002351969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001706692,"threshold_uncertainty_score":0.005709469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008274549771138078,"score_gpt":0.2180907465618436,"score_spread":0.2098161967907055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}