{"id":"W1980397367","doi":"10.1111/micc.12161","title":"Pretreatment of Human Cerebrovascular Endothelial Cells with <scp>CO</scp>‐releasing Molecule‐3 Interferes with <scp>JNK</scp>/<scp>AP</scp>‐1 Signaling and Suppresses <scp>LPS</scp>‐induced Proadhesive Phenotype","year":2014,"lang":"en","type":"article","venue":"Microcirculation","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Lawson Health Research Institute","funders":"Heart and Stroke Foundation of Canada","keywords":"p38 mitogen-activated protein kinases; Phosphorylation; Chemistry; MAPK/ERK pathway; Western blot; Cell adhesion molecule; Cell biology; Signal transduction; Downregulation and upregulation; Stimulation; Molecular biology; Pharmacology; Biochemistry; Biology; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003622457,0.0008558368,0.0007802101,0.0002352139,0.0003598393,0.0002123375,0.0004089153,0.0005421114,0.000003965225],"category_scores_gemma":[0.0004324271,0.000765178,0.0002774811,0.0002956691,0.0002618827,0.00006221503,0.0001648173,0.0003513762,0.00001488984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001092127,"about_ca_system_score_gemma":0.0002164526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002223038,"about_ca_topic_score_gemma":0.00008898252,"domain_scores_codex":[0.9959855,0.000392644,0.0007433025,0.001350637,0.0005898458,0.0009380367],"domain_scores_gemma":[0.9972902,0.0003700234,0.0006839769,0.0008680827,0.0004638225,0.000323894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001792041,0.0002455787,0.009275055,0.0002995581,0.0006675679,0.00001334564,0.002078881,0.001116962,0.98541,0.00004876049,0.0004473379,0.0003789942],"study_design_scores_gemma":[0.00262285,0.001479867,0.005171688,0.0002503377,0.0004455363,0.00005299666,0.002006146,0.0002989882,0.9844724,0.0000751143,0.002987858,0.000136238],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901438,0.001369403,0.005209601,0.000007898384,0.00009107641,0.001180037,0.00008201993,0.00008569512,0.001830445],"genre_scores_gemma":[0.9963737,0.0001170089,0.001581043,0.0001481146,0.0003747736,0.0001080859,0.0005415133,0.000193296,0.0005624646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006229876,"threshold_uncertainty_score":0.9994799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008274549771138078,"score_gpt":0.2180907465618436,"score_spread":0.2098161967907055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}