{"id":"W1980422861","doi":"10.1038/ni.2246","title":"Protein tyrosine phosphatases in lymphocyte activation and autoimmunity","year":2012,"lang":"en","type":"review","venue":"Nature Immunology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":221,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"Autoimmunity; Protein tyrosine phosphatase; Cell biology; Biology; Lymphocyte; Signal transduction; Receptor; Intracellular; Immunology; Lymphocyte activation; Immune system; T cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0003246625,0.0005776886,0.001045881,0.0002151437,0.00009241929,0.00003068396,0.0004806341,0.002316499,0.00002972077],"category_scores_gemma":[0.0004186847,0.0005164534,0.0001611633,0.0003093297,0.0002516771,0.00001705169,0.0005647322,0.001188814,0.00002277046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001397629,"about_ca_system_score_gemma":0.0003798951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001217363,"about_ca_topic_score_gemma":0.00002449338,"domain_scores_codex":[0.9978558,0.0003583563,0.0005276434,0.0006060231,0.0001204421,0.0005317496],"domain_scores_gemma":[0.9985636,0.00005380343,0.0004118856,0.0008429334,0.00006795314,0.00005978024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001203813,0.0001293248,0.00001036511,0.002094501,0.0001981919,0.000007520831,0.000007780715,1.278569e-7,0.003121978,0.002748467,0.0001700919,0.9913912],"study_design_scores_gemma":[0.0005862223,0.0001497313,0.0001344137,0.001988986,0.0001242381,0.0001040398,0.000003912333,2.215482e-7,0.0511087,0.00006278602,0.945264,0.0004727788],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003480548,0.9977399,0.00001999378,0.00003290837,0.0002661621,0.001256065,0.0002338393,0.000031254,0.00007182926],"genre_scores_gemma":[0.003329126,0.9911991,0.000339874,0.00009047437,0.0002037226,0.0004488216,0.004162399,0.00008148006,0.0001450518],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9909185,"threshold_uncertainty_score":0.9997287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0169313923649197,"score_gpt":0.2973480496688399,"score_spread":0.2804166573039202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}