{"id":"W1980429333","doi":"10.1016/j.cell.2014.02.055","title":"The Intrinsic Apoptosis Pathway Mediates the Pro-Longevity Response to Mitochondrial ROS in C. elegans","year":2014,"lang":"en","type":"article","venue":"Cell","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":363,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Mitochondrion; Cell biology; Apoptosis; Mitochondrial ROS; Caenorhabditis elegans; Signal transduction; Reactive oxygen species; Longevity; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001289648,0.0003860093,0.0002609847,0.0003446616,0.0003663115,0.0004003299,0.000423964,0.0003660223,0.0008537658],"category_scores_gemma":[0.0001716776,0.0001758024,0.0002044806,0.00009448586,0.0003384954,0.0004067842,0.0003167674,0.0007956908,0.0002096767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006855917,"about_ca_system_score_gemma":0.0005932152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001570868,"about_ca_topic_score_gemma":0.003660564,"domain_scores_codex":[0.9998664,0.00001085282,0.00001174002,0.00003126472,0.00004688133,0.00003300657],"domain_scores_gemma":[0.9998063,0.00001937895,0.00005431634,0.00002270571,0.00004367155,0.00005362075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008226734,0.00001397655,0.0002973192,0.00002962884,0.000002988468,0.00007725288,0.000009104519,0.0001220765,0.997915,0.0003364112,0.00004258618,0.001071361],"study_design_scores_gemma":[0.00002331059,0.0001493438,0.01117446,0.00001971757,0.00002217836,0.0003141169,0.00004431421,0.002783057,0.983335,0.00033521,0.001785549,0.00001366489],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935348,0.001455863,0.003384117,0.0001878559,0.00003937246,0.00001094784,0.0003042298,0.0001014381,0.0009815494],"genre_scores_gemma":[0.9948168,0.0009100921,0.00170604,0.00004024823,0.000006384382,0.00001799425,0.0002016877,0.00002172746,0.002278851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001570868,"threshold_uncertainty_score":0.004974306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006391912437023593,"score_gpt":0.209638490072294,"score_spread":0.2032465776352704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}