{"id":"W1980430640","doi":"10.1016/j.jsbmb.2005.07.006","title":"Dehydroepiandrosterone (DHEA) metabolism in the brain: Identification by liquid chromatography/mass spectrometry of the delta-4-isomer of DHEA and related steroids formed from androstenedione by mouse BV2 microglia","year":2005,"lang":"en","type":"article","venue":"The Journal of Steroid Biochemistry and Molecular Biology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging; National Institutes of Health","keywords":"Dehydroepiandrosterone; Chemistry; Androstenediol; Androstenedione; Testosterone (patch); Androsterone; Metabolite; Pregnenolone; Neuroactive steroid; Androgen; Epimer; Dihydrotestosterone; Metabolism; Mass spectrometry; Biochemistry; Steroid; Endocrinology; Chromatography; Hormone; Stereochemistry; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001398595,0.0005993976,0.0002826939,0.0007072483,0.0005497903,0.0005190775,0.0002540716,0.0003091726,0.001129368],"category_scores_gemma":[0.0001530871,0.0002678912,0.0003230399,0.0003331085,0.0003548385,0.0003900972,0.0001974117,0.0006284216,0.0005650723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005675064,"about_ca_system_score_gemma":0.0005066422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002955567,"about_ca_topic_score_gemma":0.004830425,"domain_scores_codex":[0.999905,0.000007775686,0.000003921721,0.00001952597,0.00002729774,0.00003651844],"domain_scores_gemma":[0.999903,0.00000882722,0.0000202312,0.000007789074,0.00002418715,0.00003600755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002991269,0.00001337183,0.0003276706,0.00002023748,0.00001093198,0.0001045263,0.00002203518,0.00001306367,0.9977373,0.00007216078,0.00003066616,0.001348957],"study_design_scores_gemma":[0.00001896244,0.00012032,0.01184894,0.000007557266,0.00003525932,0.0005060915,0.00008933817,0.0001548773,0.9855356,0.0001461121,0.001528283,0.000008720171],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801743,0.009508277,0.005793151,0.0003504877,0.00007414636,0.0000415347,0.001543641,0.0001101127,0.002404388],"genre_scores_gemma":[0.9744736,0.007560495,0.005927115,0.0002840623,0.00007568693,0.0001025481,0.001846964,0.00008507229,0.009644395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002955567,"threshold_uncertainty_score":0.00587672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002657526196901565,"score_gpt":0.214492562725907,"score_spread":0.2118350365290054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}