{"id":"W1980466176","doi":"10.1371/journal.pone.0021296","title":"SMA CARNI-VAL TRIAL PART II: A Prospective, Single-Armed Trial of L-Carnitine and Valproic Acid in Ambulatory Children with Spinal Muscular Atrophy","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; University of Manitoba","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Research Resources; National Institutes of Health; Johns Hopkins University; Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston; Children's Hospital of Michigan; Ohio State University; Families of Spinal Muscular Atrophy","keywords":"Spinal muscular atrophy; Medicine; SMA*; Ambulatory; Valproic Acid; Adverse effect; Prospective cohort study; Clinical trial; Compound muscle action potential; Pulmonary function testing; Pediatrics; Internal medicine; Physical therapy; Epilepsy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00120729,0.001309279,0.001848598,0.0003056515,0.00040442,0.0008170744,0.000548215,0.001530359,0.003886525],"category_scores_gemma":[0.0007995562,0.0004274332,0.001191207,0.0002782593,0.0007088309,0.0005058419,0.0003464119,0.002110109,0.0006042905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006062175,"about_ca_system_score_gemma":0.001292325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008685514,"about_ca_topic_score_gemma":0.002435907,"domain_scores_codex":[0.9995238,0.0002587461,0.00002890286,0.00007460286,0.00003788597,0.0000760309],"domain_scores_gemma":[0.9993069,0.0001393399,0.0001678866,0.00004209757,0.00003887871,0.0003049977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9252419,0.01464897,0.01096374,0.00109173,0.001597131,0.0003848582,0.0001977574,0.0006326499,0.01232767,0.0002448643,0.001831977,0.03083663],"study_design_scores_gemma":[0.8253447,0.1547695,0.01625957,0.00008123248,0.0004836707,0.0003093158,0.00004045205,0.0002918904,0.0008520661,0.00008533453,0.001463229,0.00001904712],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919566,0.004175705,0.000212301,0.0003900666,0.000060534,0.001390268,0.0007887089,0.00003125738,0.0009945916],"genre_scores_gemma":[0.9837695,0.002782904,0.001829517,0.001174618,0.0003030561,0.004249883,0.00318002,0.00002060598,0.002689967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003886525,"threshold_uncertainty_score":0.01300168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07477081700430174,"score_gpt":0.2511769320311867,"score_spread":0.1764061150268849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}