{"id":"W1980466176","doi":"10.1371/journal.pone.0021296","title":"SMA CARNI-VAL TRIAL PART II: A Prospective, Single-Armed Trial of L-Carnitine and Valproic Acid in Ambulatory Children with Spinal Muscular Atrophy","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; University of Manitoba","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Research Resources; National Institutes of Health; Johns Hopkins University; Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston; Children's Hospital of Michigan; Ohio State University; Families of Spinal Muscular Atrophy","keywords":"Spinal muscular atrophy; Medicine; SMA*; Ambulatory; Valproic Acid; Adverse effect; Prospective cohort study; Clinical trial; Compound muscle action potential; Pulmonary function testing; Pediatrics; Internal medicine; Physical therapy; Epilepsy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002695285,0.0002324683,0.0006904563,0.0002072099,0.00007222006,0.000009663004,0.0001105029,0.0001131553,0.00008655326],"category_scores_gemma":[0.0001685491,0.0001920279,0.0001439141,0.0003158714,0.0003089666,0.00005388532,0.0001015462,0.000371755,0.000004241855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004387083,"about_ca_system_score_gemma":0.0002101233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008941113,"about_ca_topic_score_gemma":0.00002552359,"domain_scores_codex":[0.9977786,0.0001334779,0.000396929,0.0004904984,0.000800559,0.0003999415],"domain_scores_gemma":[0.9990996,0.00001444092,0.0001243537,0.0004041435,0.000160126,0.0001973277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.740303,0.02703552,0.1659259,0.0005228212,0.00237882,0.0001279005,0.00138371,5.827353e-7,0.05892737,0.00006836755,0.00001837444,0.003307556],"study_design_scores_gemma":[0.6271985,0.0669721,0.2193918,0.0006013521,0.001326216,0.00004682942,0.0001531018,0.00003251467,0.0837339,0.00008391714,0.00004381846,0.0004159921],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942095,0.0007548805,0.000009792246,0.00006933575,0.00003241848,0.004193569,0.000007162757,0.00003559275,0.000687741],"genre_scores_gemma":[0.998031,0.0001457281,0.001070386,0.00003066274,0.0002794673,0.0002475769,0.0000157791,0.00005033038,0.0001290811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1131046,"threshold_uncertainty_score":0.7830671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07477081700430174,"score_gpt":0.2511769320311867,"score_spread":0.1764061150268849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}