{"id":"W1980473329","doi":"10.1038/sj.leu.2402444","title":"Elucidating critical mechanisms of deregulated stem cell turnover in the chronic phase of chronic myeloid leukemia","year":2002,"lang":"en","type":"review","venue":"Leukemia","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":126,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Stem cell; Haematopoiesis; clone (Java method); Biology; Progenitor cell; Stem cell theory of aging; Myeloid leukemia; Myeloid; Cancer research; Autocrine signalling; Immunology; Cell biology; Leukemia; Genetics; Stem cell factor; Cell culture; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0008659147,0.001278057,0.004557113,0.0006153537,0.0001033154,0.00003537233,0.00106548,0.001297164,0.001001662],"category_scores_gemma":[0.0001407964,0.0009076154,0.00128244,0.001490275,0.0004262947,0.0001612702,0.0002098178,0.002040453,0.0001734635],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.02920795,"about_ca_system_score_gemma":0.01043312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002609647,"about_ca_topic_score_gemma":0.00007146292,"domain_scores_codex":[0.992735,0.0006165329,0.0028943,0.00118884,0.001323573,0.001241714],"domain_scores_gemma":[0.9946433,0.001307277,0.001359636,0.002229208,0.0001960919,0.0002644628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008633078,0.0008995858,0.000002907439,0.1004666,0.0006615132,0.0007358938,0.0007035205,0.00006730128,0.001046087,0.0007685993,0.001079553,0.8934821],"study_design_scores_gemma":[0.04674296,0.008127008,0.00003522549,0.1837779,0.01824644,0.003517773,0.0005489597,0.007571066,0.0188348,0.0004697497,0.708674,0.003454174],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00255403,0.9911364,0.0003423839,0.00002483999,0.0003360895,0.002941332,0.0001749127,0.00008730562,0.002402761],"genre_scores_gemma":[0.04667384,0.9501188,0.0004417837,0.00006379299,0.0005347875,0.0003140385,0.0004396194,0.0002777348,0.00113555],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8900279,"threshold_uncertainty_score":0.9999993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04371995112838308,"score_gpt":0.3315971371142519,"score_spread":0.2878771859858688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}