{"id":"W1980495419","doi":"10.1016/j.bbrc.2015.01.040","title":"Functional properties of Claramine: A novel PTP1B inhibitor and insulin-mimetic compound","year":2015,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Canadian Institutes of Health Research; Canadian Diabetes Association; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Insulin receptor; Insulin; Internal medicine; Insulin resistance; Endocrinology; Glucose homeostasis; Protein kinase B; Type 2 diabetes; Protein tyrosine phosphatase; Intraperitoneal injection; Diabetes mellitus; Glycemic; Homeostasis; Chemistry; Biology; Phosphorylation; Receptor; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001806165,0.0002235265,0.0002272961,0.0001484484,0.0001186686,0.0001972411,0.0004106222,0.0003553177,0.001209907],"category_scores_gemma":[0.0001977666,0.0001080487,0.0001553797,0.00009895437,0.0001386897,0.0002383698,0.0001069506,0.0003723456,0.0003162508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002234973,"about_ca_system_score_gemma":0.0001201441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004798025,"about_ca_topic_score_gemma":0.0002720916,"domain_scores_codex":[0.999893,0.00002007639,0.0000104797,0.00002472058,0.00002524568,0.0000264923],"domain_scores_gemma":[0.9998969,0.00002671939,0.00002184674,0.00000713487,0.00001875635,0.00002868968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006569882,0.00002749434,0.00007895939,0.0000397537,0.000006809195,0.00005749493,0.000007779564,0.00005426355,0.9972489,0.00007261957,0.00005361479,0.001695264],"study_design_scores_gemma":[0.00004790797,0.0004395044,0.001463046,0.000003328159,0.00002399277,0.0002313858,0.000007058195,0.0007965173,0.9954427,0.0000114183,0.00152812,0.000004995435],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903689,0.005314527,0.001525525,0.000132983,0.00003835247,0.00002529069,0.000278626,0.00005459684,0.002261213],"genre_scores_gemma":[0.9952549,0.001100669,0.00115455,0.00005464468,0.00001633773,0.00001555443,0.0004453634,0.00001250173,0.001945532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001209907,"threshold_uncertainty_score":0.004047573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1457649435641149,"score_gpt":0.3409951588258352,"score_spread":0.1952302152617203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}