{"id":"W1980495419","doi":"10.1016/j.bbrc.2015.01.040","title":"Functional properties of Claramine: A novel PTP1B inhibitor and insulin-mimetic compound","year":2015,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Canadian Institutes of Health Research; Canadian Diabetes Association; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Insulin receptor; Insulin; Internal medicine; Insulin resistance; Endocrinology; Glucose homeostasis; Protein kinase B; Type 2 diabetes; Protein tyrosine phosphatase; Intraperitoneal injection; Diabetes mellitus; Glycemic; Homeostasis; Chemistry; Biology; Phosphorylation; Receptor; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003363751,0.0001118571,0.0001452819,0.00004895429,0.0001308488,0.00003560912,0.0003492873,0.0001109915,0.000001391612],"category_scores_gemma":[0.0008973348,0.00009069246,0.00003615659,0.0002060888,0.001719808,0.000008846537,0.001042465,0.0002361375,0.000004761487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001506586,"about_ca_system_score_gemma":0.0001435412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008051154,"about_ca_topic_score_gemma":0.000004471903,"domain_scores_codex":[0.99893,0.0001027387,0.0001951644,0.0002610939,0.0003038988,0.0002070959],"domain_scores_gemma":[0.9985552,0.00007811221,0.00004177345,0.0006577071,0.0004514795,0.0002156866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001685932,0.0003765215,0.00007307163,0.00003769844,0.00002327251,1.673619e-7,0.00002134573,1.884915e-7,0.9924178,0.00389549,0.002148651,0.0008372688],"study_design_scores_gemma":[0.0006349825,0.000318957,0.0008170329,0.00004682919,0.00001007721,0.00000872775,0.00007835218,0.0001780293,0.9902526,0.0004982158,0.00703783,0.0001183294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9672596,0.03012293,0.0001144537,0.002011982,0.0000167581,0.0002704158,0.00007863849,0.00001032028,0.0001148882],"genre_scores_gemma":[0.9966086,0.0008438252,0.002061149,0.00005136058,0.000111978,0.00006772263,0.0001771537,0.00001100519,0.00006724698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02934894,"threshold_uncertainty_score":0.6336703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1457649435641149,"score_gpt":0.3409951588258352,"score_spread":0.1952302152617203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}