{"id":"W1980536475","doi":"10.1371/journal.pone.0087210","title":"Chimeric Antibody c.8B6 to O-Acetyl-GD2 Mediates the Same Efficient Anti-Neuroblastoma Effects as Therapeutic ch14.18 Antibody to GD2 without Antibody Induced Allodynia","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; Ligue Contre le Cancer; National Institutes of Health; Agence Nationale de la Recherche","keywords":"Neuroblastoma; Antibody; Medicine; Immunotherapy; Monoclonal antibody; Immunogenicity; Cancer research; Pharmacology; Adverse effect; Immunology; Immune system; Biology; Cell culture","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001661168,0.0004767431,0.0002474515,0.0002149826,0.0001096209,0.0001404199,0.0002837659,0.0003904931,0.001825668],"category_scores_gemma":[0.0001207826,0.00008836003,0.0003040214,0.00008460506,0.0002309317,0.0001512327,0.0001224918,0.0007154288,0.0003342483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000377715,"about_ca_system_score_gemma":0.0002946937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008807397,"about_ca_topic_score_gemma":0.0008768527,"domain_scores_codex":[0.9998288,0.00001571172,0.00001162339,0.00004020004,0.00005083733,0.00005270792],"domain_scores_gemma":[0.9998946,0.00001358146,0.00003036163,0.00001133612,0.00001947495,0.00003068547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001390269,0.00005369654,0.00007835335,0.00002717012,0.000003583559,0.00001901138,0.000003524907,0.00003004816,0.9988534,0.00004647385,0.00002609676,0.0007195519],"study_design_scores_gemma":[0.00003951544,0.0008015125,0.001642963,0.00000611965,0.00001488635,0.000250734,0.000006206655,0.0004006909,0.9954877,0.00001414586,0.001333238,0.000002284255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934866,0.001548337,0.002465932,0.00007364948,0.00004368142,0.000062231,0.000226847,0.00007491144,0.0020177],"genre_scores_gemma":[0.9936309,0.000523246,0.002857284,0.00006757375,0.00001519432,0.00006466122,0.0004880147,0.00001766388,0.002335527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001825668,"threshold_uncertainty_score":0.00610745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03133481732709893,"score_gpt":0.3256621853303243,"score_spread":0.2943273680032254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}