{"id":"W1980536475","doi":"10.1371/journal.pone.0087210","title":"Chimeric Antibody c.8B6 to O-Acetyl-GD2 Mediates the Same Efficient Anti-Neuroblastoma Effects as Therapeutic ch14.18 Antibody to GD2 without Antibody Induced Allodynia","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; Ligue Contre le Cancer; National Institutes of Health; Agence Nationale de la Recherche","keywords":"Neuroblastoma; Antibody; Medicine; Immunotherapy; Monoclonal antibody; Immunogenicity; Cancer research; Pharmacology; Adverse effect; Immunology; Immune system; Biology; Cell culture","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006309708,0.000875832,0.001429569,0.0006503849,0.0004656819,0.0001927039,0.000778185,0.0002037899,0.000181564],"category_scores_gemma":[0.0009993295,0.0006085454,0.0002704182,0.00161746,0.0002189158,0.0001321443,0.0004598651,0.000829363,0.003659616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001375712,"about_ca_system_score_gemma":0.000224509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001818544,"about_ca_topic_score_gemma":0.00002358299,"domain_scores_codex":[0.9934436,0.000633421,0.0006558695,0.001372023,0.00219773,0.001697352],"domain_scores_gemma":[0.9956303,0.000741648,0.0002153779,0.001693368,0.0003539103,0.001365364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007687914,0.004903208,0.03086361,0.0003375073,0.0009613093,0.0001868362,0.0005964411,0.00002965599,0.9597508,0.00003137646,0.0001030283,0.001467419],"study_design_scores_gemma":[0.004455743,0.01043074,0.3841689,0.00110582,0.0007666506,0.0001097004,0.00006202049,0.001454885,0.5963439,0.00002914625,0.0003969847,0.0006754576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882499,0.0001610106,0.0002170663,0.004761667,0.0002888122,0.004569178,0.00002473327,0.0004279215,0.001299686],"genre_scores_gemma":[0.9926877,0.0001282125,0.0006175916,0.00488245,0.0004752213,0.000223654,0.0001206001,0.0002386246,0.0006259296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3634069,"threshold_uncertainty_score":0.9996366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03133481732709893,"score_gpt":0.3256621853303243,"score_spread":0.2943273680032254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}