{"id":"W1980543089","doi":"10.1016/j.nucmedbio.2014.09.011","title":"Preclinical pharmacokinetics, biodistribution, radiation dosimetry and acute toxicity studies required for regulatory approval of a Clinical Trial Application for a Phase I/II clinical trial of 111In-BzDTPA-pertuzumab","year":2014,"lang":"en","type":"article","venue":"Nuclear Medicine and Biology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Juravinski Cancer Centre; University Health Network; McMaster University; Ontario Institute for Cancer Research; University of Toronto","funders":"Ontario Institute for Cancer Research","keywords":"Biodistribution; Clinical trial; Pharmacokinetics; Dosimetry; Medicine; Pharmacology; Regulatory authority; Medical physics; Toxicity; Oncology; Nuclear medicine; Internal medicine; In vivo; Biotechnology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01087436,0.0007722298,0.001470666,0.000510451,0.001105989,0.002337284,0.00100089,0.001798231,0.00528042],"category_scores_gemma":[0.006998975,0.0007781361,0.001180102,0.0007164812,0.00114947,0.00134616,0.0004597963,0.00292709,0.002404518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001421177,"about_ca_system_score_gemma":0.005273932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001548109,"about_ca_topic_score_gemma":0.002236775,"domain_scores_codex":[0.9965944,0.00194164,0.0001661657,0.0001895385,0.0006740763,0.0004341104],"domain_scores_gemma":[0.9966665,0.0007688486,0.0005922765,0.000596733,0.0006242146,0.0007513678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.06486793,0.01830045,0.01363906,0.0006591157,0.0004450892,0.001099626,0.0008199835,0.01308447,0.770342,0.006152171,0.02185751,0.08873253],"study_design_scores_gemma":[0.02099163,0.228786,0.071819,0.0002661993,0.001634232,0.006268776,0.0007862045,0.01451246,0.4568219,0.009291585,0.1886042,0.0002177489],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8311775,0.006001289,0.09710697,0.004389582,0.0006422531,0.02046161,0.009841614,0.0008598379,0.02951927],"genre_scores_gemma":[0.9319638,0.001480418,0.03228497,0.002544709,0.000290247,0.008533156,0.01318559,0.0004871541,0.009229885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01087436,"threshold_uncertainty_score":0.05750978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3390109953650138,"score_gpt":0.5810161384611477,"score_spread":0.242005143096134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}