{"id":"W1980573720","doi":"10.1038/sj.cdd.4401629","title":"Cellular prion protein inhibits proapoptotic Bax conformational change in human neurons and in breast carcinoma MCF-7 cells","year":2005,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":163,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Institute of Neurological Disorders and Stroke; Université de Genève; Case Western Reserve University","keywords":"Staurosporine; Programmed cell death; Apoptosis; Cytochrome c; Cell biology; Bcl-2-associated X protein; Mitochondrion; MCF-7; Chemistry; Caspase; Thapsigargin; Biology; Molecular biology; Signal transduction; Caspase 3; Cancer cell; Biochemistry; Protein kinase C; Intracellular; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002413991,0.0002319556,0.0003490278,0.0002563589,0.0002752581,0.0002571662,0.0002174967,0.000272449,0.001053488],"category_scores_gemma":[0.0002432252,0.0001589918,0.0002996109,0.0002508096,0.0002006373,0.0001479781,0.0001340621,0.0005284385,0.0003226945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002693348,"about_ca_system_score_gemma":0.0002416508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002333845,"about_ca_topic_score_gemma":0.002746,"domain_scores_codex":[0.9997783,0.00006792194,0.00002443537,0.00002003431,0.0000455849,0.0000637062],"domain_scores_gemma":[0.9997869,0.00009838059,0.00001566224,0.00003834674,0.00002844347,0.00003221863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005779655,0.0001200475,0.0002661537,0.00007721022,0.00002336712,0.000181207,0.0000699536,0.00009755541,0.9972403,0.0001358942,0.000130788,0.001079533],"study_design_scores_gemma":[0.0000499831,0.0005978931,0.003970847,0.000007965084,0.0000347243,0.0004683506,0.00007652985,0.0006692039,0.9923914,0.00005430356,0.001673943,0.00000470109],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996033,0.002056991,0.0005288041,0.00008367344,0.00002935234,0.00001454877,0.0002566328,0.00002429188,0.0009726582],"genre_scores_gemma":[0.9951793,0.001328182,0.0005855578,0.00003652745,0.00001357667,0.00002200117,0.0008385485,0.00001352745,0.001982875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002333845,"threshold_uncertainty_score":0.00464046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01082186689269808,"score_gpt":0.2175261910091338,"score_spread":0.2067043241164358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}