{"id":"W1980580505","doi":"10.1111/j.1471-4159.2008.05657.x","title":"Mitogen‐activated protein kinase activity may not be necessary for the neuropathology of Niemann–Pick type C mice","year":2008,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute on Aging","keywords":"Hyperphosphorylation; Neuropathology; MAPK/ERK pathway; Kinase; Cytoskeleton; Mitogen-activated protein kinase; Biology; Neuroscience; Protein kinase A; Internal medicine; Neurofilament; Cell biology; Endocrinology; Medicine; Cancer research; Disease; Biochemistry; Cell; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000238747,0.0001678866,0.0004047954,0.00007308168,0.0001153742,0.000007979127,0.0003444368,0.0001261659,0.00004682757],"category_scores_gemma":[0.001956452,0.0001185409,0.0002273726,0.0002772356,0.0002285345,0.00009103754,0.00008039775,0.0007114349,0.000001902852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004621321,"about_ca_system_score_gemma":0.0003712473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000012382,"about_ca_topic_score_gemma":4.050859e-7,"domain_scores_codex":[0.998514,0.0000901992,0.0003943406,0.000200685,0.0005269113,0.0002738669],"domain_scores_gemma":[0.9980024,0.0003483995,0.0004486979,0.000329059,0.0007194445,0.000151972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004002575,0.0003569024,0.0009190094,0.000292245,0.00007318644,0.000898874,0.000109135,0.000009826065,0.9903274,0.000001289984,0.00232507,0.000684534],"study_design_scores_gemma":[0.001953881,0.0008374072,0.02133689,0.00006310856,0.00008238517,0.003209299,0.0000687375,0.00005150655,0.9677593,0.000005935838,0.004538818,0.0000927201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915218,0.0003327796,0.00005863357,0.007360457,0.0001737035,0.0003730316,0.00001114578,0.00001067485,0.0001578203],"genre_scores_gemma":[0.9976805,0.0001314007,0.0001746468,0.0003734857,0.0002568502,0.000009282008,0.000002736989,0.00003452128,0.00133659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02256805,"threshold_uncertainty_score":0.4833956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05971586786451454,"score_gpt":0.3241986801865658,"score_spread":0.2644828123220512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}