{"id":"W1980623031","doi":"10.1523/jneurosci.4518-13.2015","title":"Use-Dependent Activation of Neuronal Kv1.2 Channel Complexes","year":2015,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Faculty of Medicine, University of British Columbia; Canadian Institutes of Health Research; Michael Smith Health Research BC; University of British Columbia; Heart and Stroke Foundation of Canada","keywords":"Depolarization; Potassium channel; Neuroscience; Shaker; Biophysics; Ion channel; Hippocampal formation; Long-term potentiation; Protein subunit; HEK 293 cells; SK channel; Biology; Cell biology; Chemistry; Physics; Cell culture; Biochemistry; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001039592,0.0002397045,0.0001835088,0.0001531445,0.0001368449,0.0003518157,0.000252802,0.0001847312,0.0006929843],"category_scores_gemma":[0.0002215234,0.000133259,0.0002563797,0.0001251103,0.000192889,0.0003993318,0.0003768915,0.0003242503,0.0002459799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003264849,"about_ca_system_score_gemma":0.0001192124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003047818,"about_ca_topic_score_gemma":0.0006529273,"domain_scores_codex":[0.9997992,0.00002126773,0.00002295497,0.00005418495,0.00006803721,0.00003426559],"domain_scores_gemma":[0.9998626,0.00002000129,0.00004945355,0.00002810165,0.0000173447,0.00002242885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001889178,0.000006108838,0.0002269394,0.0000104666,0.000002914479,0.00002083912,0.000009933729,0.00001384891,0.999258,0.00005260493,0.0000133894,0.0003660379],"study_design_scores_gemma":[0.000005977541,0.000146996,0.03370714,0.000005509375,0.00001686364,0.0007192133,0.00004179602,0.0005736473,0.9630976,0.0001130136,0.001563763,0.000008469782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951783,0.0009965672,0.002152269,0.00003600641,0.00001644259,0.00001343897,0.0001493016,0.00003665147,0.001420872],"genre_scores_gemma":[0.9969331,0.0004058281,0.000955001,0.0000365552,0.000008494076,0.00002180826,0.0002748758,0.00002387665,0.001340494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006929843,"threshold_uncertainty_score":0.002368808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07884769567005702,"score_gpt":0.2888178606653719,"score_spread":0.2099701649953149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}