{"id":"W1980631512","doi":"10.1002/cbic.200400395","title":"The Oxidative Ring Cleavage in Jadomycin Biosynthesis: A Multistep Oxygenation Cascade in a Biosynthetic Black Box","year":2005,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Biosynthesis; Chemistry; Cleavage (geology); Stereochemistry; Oxygenase; Biochemistry; DNA; Oxidative phosphorylation; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006685677,0.0002729282,0.0003671605,0.0002143107,0.00009587558,0.00004874918,0.0002237365,0.0002156984,0.00006107008],"category_scores_gemma":[0.0009236612,0.0001891695,0.0001134153,0.0005637448,0.0001987322,0.0001204701,0.00008692651,0.0004279887,0.0001350684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003629448,"about_ca_system_score_gemma":0.00006561796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001316378,"about_ca_topic_score_gemma":0.0006064284,"domain_scores_codex":[0.9981347,0.00007748839,0.0005129813,0.000534592,0.0002331841,0.0005070125],"domain_scores_gemma":[0.9990233,0.0002218602,0.0001365003,0.000448285,0.00006649459,0.0001035286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002324655,0.0002392871,0.0002503636,0.00006356376,0.00003027892,0.00002472884,0.0008952193,0.000002792482,0.9566004,0.00007605019,0.0007764581,0.04080844],"study_design_scores_gemma":[0.001130889,0.00003950224,0.004819601,0.0003558155,0.00003013731,0.00002818595,0.0007006658,0.0005648384,0.9852181,0.00001909683,0.006854843,0.0002383091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839208,0.001318648,0.000004399708,0.01107533,0.00006568999,0.0006776873,0.000008488875,0.0000540228,0.002874953],"genre_scores_gemma":[0.9968335,0.0003492132,0.0008940828,0.0004136038,0.0002433312,0.000008450307,0.000009414684,0.00003499231,0.001213412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04057012,"threshold_uncertainty_score":0.7714109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01280486468053983,"score_gpt":0.2504421970326109,"score_spread":0.2376373323520711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}