{"id":"W1980641226","doi":"10.1093/nar/gku1285","title":"CRISPR RNA binding and DNA target recognition by purified Cascade complexes from Escherichia coli","year":2014,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences","keywords":"Trans-activating crRNA; CRISPR; Biology; Cas9; RNA; Escherichia coli; DNA; Plasmid; Genetics; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000536382,0.0001488465,0.0001560373,0.00007419258,0.0002005812,0.00008705394,0.0002028958,0.0001998213,0.0001087613],"category_scores_gemma":[0.0002318467,0.0001523445,0.00004179864,0.0001382626,0.0001398259,0.000005193439,0.0001873942,0.0002795367,0.00005035636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001786555,"about_ca_system_score_gemma":0.00002441746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001470837,"about_ca_topic_score_gemma":0.00002206015,"domain_scores_codex":[0.9985315,0.0001586622,0.0001734095,0.0004282186,0.0002769305,0.0004313116],"domain_scores_gemma":[0.9993491,0.00006233931,0.00002750178,0.0002867372,0.0001001321,0.0001741855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004268021,0.0000255967,0.0004297466,0.00001910025,0.00002901323,0.000001215955,0.00008233194,0.000005859265,0.9825737,0.00001144682,0.009917186,0.006862099],"study_design_scores_gemma":[0.0005070658,0.0002094947,0.002252279,0.00001915209,0.000007424032,0.00000210441,0.0001833047,0.0008175765,0.9262893,0.0002811881,0.06922899,0.0002021209],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908949,0.0007823808,0.005798877,0.0002145612,0.00008825363,0.000181296,0.0001006735,0.00002358757,0.001915536],"genre_scores_gemma":[0.9951769,0.0002840228,0.003268137,0.00008534789,0.0003078244,0.00002597655,0.0003859344,0.00004050414,0.0004254234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05931181,"threshold_uncertainty_score":0.6212428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02737764407464393,"score_gpt":0.3313801493543099,"score_spread":0.3040025052796659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}