{"id":"W1980641226","doi":"10.1093/nar/gku1285","title":"CRISPR RNA binding and DNA target recognition by purified Cascade complexes from Escherichia coli","year":2014,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences","keywords":"Trans-activating crRNA; CRISPR; Biology; Cas9; RNA; Escherichia coli; DNA; Plasmid; Genetics; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000296096,0.000531495,0.0004367033,0.0003702604,0.0002285489,0.0004524514,0.000452533,0.0003826036,0.001443757],"category_scores_gemma":[0.000396859,0.000270652,0.0002956181,0.0004977731,0.0001479763,0.0002052813,0.000275528,0.0007148774,0.0007672986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006590121,"about_ca_system_score_gemma":0.0002752384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002842287,"about_ca_topic_score_gemma":0.003791775,"domain_scores_codex":[0.999477,0.00009859088,0.00004479436,0.0001058975,0.0001570626,0.0001166899],"domain_scores_gemma":[0.9998062,0.0000549339,0.00002689674,0.00002430975,0.00004891811,0.00003880799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00010554,0.00004798307,0.0001749574,0.00004725047,0.00001050987,0.00003198603,0.00002121473,0.0001733312,0.9979963,0.0001380792,0.0001582289,0.001094716],"study_design_scores_gemma":[0.00004110827,0.0001229133,0.002442204,0.00001172365,0.00001575498,0.0001507391,0.00002226534,0.002876825,0.9906911,0.00008611878,0.003525283,0.00001389195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9684178,0.003053369,0.02105483,0.0003689733,0.00008434389,0.0001670794,0.001794063,0.0002468975,0.004812603],"genre_scores_gemma":[0.9640206,0.001230452,0.0178892,0.0002751505,0.00002856024,0.0001043974,0.007202086,0.000121734,0.009127793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002842287,"threshold_uncertainty_score":0.005651534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02737764407464393,"score_gpt":0.3313801493543099,"score_spread":0.3040025052796659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}