{"id":"W1980648235","doi":"10.1016/j.febslet.2012.01.007","title":"Crystal structures of the coil 2B fragment and the globular tail domain of human lamin B1","year":2012,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Canadian Institutes of Health Research; Ministry of Science and Technology of the People's Republic of China; National Natural Science Foundation of China; Wellcome Trust","keywords":"Lamin; Nuclear lamina; Coiled coil; Domain (mathematical analysis); Crystallography; Biophysics; Nuclear matrix; Intermediate filament; Chemistry; Biology; Cell biology; Nucleus; Biochemistry; Gene; Chromatin; Nuclear protein; Cytoskeleton","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001169663,0.00007583221,0.00009187569,0.000009570786,0.00006676781,0.000005838765,0.0001089265,0.00005389311,0.000018068],"category_scores_gemma":[0.00001257869,0.00004192132,0.00006344633,0.00003014009,0.0002534399,0.000002449631,0.00008233017,0.00005732005,2.603281e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004409447,"about_ca_system_score_gemma":0.000004575064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004229534,"about_ca_topic_score_gemma":0.00001234149,"domain_scores_codex":[0.9995189,0.00006653592,0.0001129336,0.0000890223,0.0001005987,0.0001120117],"domain_scores_gemma":[0.9996406,0.000007810142,0.00008726538,0.0002313434,0.00001327053,0.00001966496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006414448,0.000006911834,0.006311873,0.00001502829,0.0000474866,1.299857e-7,0.0002421873,0.000007511124,0.9884174,0.001572828,0.003076009,0.0002384929],"study_design_scores_gemma":[0.002475911,0.0001770388,0.2629558,0.00002020737,0.0001086422,0.00002905025,0.000474555,0.000004192942,0.6614394,0.0007759787,0.07130873,0.0002305883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998154,0.0003472031,0.000117403,0.000792074,0.0002016553,0.0001187015,0.000009237787,0.000001983434,0.0002576855],"genre_scores_gemma":[0.9986124,0.000008069577,0.0001322708,0.000996622,0.0001976138,0.000003217279,0.00000965635,0.000007777418,0.00003236606],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3269781,"threshold_uncertainty_score":0.1709502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003839187018958056,"score_gpt":0.1972850238247415,"score_spread":0.1934458368057834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}