{"id":"W1980704335","doi":"10.1128/mcb.20.5.1526-1536.2000","title":"Molecular Mechanism for the Shp-2 Tyrosine Phosphatase Function in Promoting Growth Factor Stimulation of Erk Activity","year":2000,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":231,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Royal Victoria Hospital","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health","keywords":"Biology; Protein tyrosine phosphatase; Stimulation; MAPK/ERK pathway; Cell biology; Phosphatase; Mechanism (biology); Function (biology); Growth factor; Dual-specificity phosphatase; DUSP6; Biochemistry; Phosphorylation; Protein phosphatase 2; Endocrinology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002355683,0.0002375882,0.0002408259,0.0000528799,0.00008977021,0.00001721732,0.0001819096,0.0002301021,0.00003309962],"category_scores_gemma":[0.0001379079,0.0001978083,0.0001167204,0.0001395183,0.0001263746,0.000009182678,0.00008196432,0.0001088917,0.000001745287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001266967,"about_ca_system_score_gemma":0.00004015721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001331294,"about_ca_topic_score_gemma":0.00001435515,"domain_scores_codex":[0.9986827,0.0001349745,0.0002783737,0.0004904835,0.00009499305,0.0003184187],"domain_scores_gemma":[0.9993204,0.0000364129,0.0001234789,0.0003617071,0.00009837189,0.00005961941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004124092,0.00008618367,0.0005160525,0.00004902668,0.00006226468,0.000004696613,0.00001866085,0.0001078602,0.9725792,0.01179482,0.00001051992,0.01435834],"study_design_scores_gemma":[0.001106959,0.0006850592,0.0007880441,0.00001587926,0.00005524678,0.000005080173,0.000007121836,0.001347395,0.9922019,0.003132944,0.000442936,0.0002114208],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8854061,0.01105631,0.1022465,0.0001711564,0.00007312521,0.0008499504,0.0001606666,0.00001267506,0.00002345373],"genre_scores_gemma":[0.9983078,0.0001783195,0.0005802692,0.0002232559,0.00004425041,0.0001268842,0.0004875341,0.00003236634,0.00001930842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1129017,"threshold_uncertainty_score":0.8066388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008153124601243834,"score_gpt":0.2303969258665292,"score_spread":0.2222438012652853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}