{"id":"W1980704335","doi":"10.1128/mcb.20.5.1526-1536.2000","title":"Molecular Mechanism for the Shp-2 Tyrosine Phosphatase Function in Promoting Growth Factor Stimulation of Erk Activity","year":2000,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":231,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Royal Victoria Hospital","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health","keywords":"Biology; Protein tyrosine phosphatase; Stimulation; MAPK/ERK pathway; Cell biology; Phosphatase; Mechanism (biology); Function (biology); Growth factor; Dual-specificity phosphatase; DUSP6; Biochemistry; Phosphorylation; Protein phosphatase 2; Endocrinology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001433047,0.0006201758,0.0001967214,0.0001733792,0.0001604955,0.000283813,0.0002091073,0.0002643543,0.001289392],"category_scores_gemma":[0.00007498488,0.0001555638,0.0003402794,0.00008552557,0.0002238964,0.0002603296,0.0002929424,0.0005248159,0.0004101406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002071101,"about_ca_system_score_gemma":0.0001834794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002669025,"about_ca_topic_score_gemma":0.0002600366,"domain_scores_codex":[0.9999311,0.000009731213,0.000004330308,0.00001389935,0.00001917863,0.00002176179],"domain_scores_gemma":[0.9999645,0.000005622442,0.000006448824,0.000004776216,0.000005929032,0.00001267815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001248285,0.00003306728,0.0003618374,0.0000602615,0.000009636397,0.0002258463,0.000008535764,0.0001131833,0.9974036,0.0003811437,0.00004756228,0.00123054],"study_design_scores_gemma":[0.0000613278,0.0002368127,0.007929069,0.000007877339,0.00001808324,0.0007371274,0.00002728975,0.001978742,0.9863362,0.0002744922,0.00238631,0.000006625999],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849347,0.005208552,0.006408737,0.0003266298,0.00006301849,0.00006479891,0.0002963223,0.0000958661,0.002601403],"genre_scores_gemma":[0.9946601,0.001518599,0.001351672,0.00004457099,0.00002404588,0.00005251656,0.0002068683,0.00000630505,0.002135399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001289392,"threshold_uncertainty_score":0.004313469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008153124601243834,"score_gpt":0.2303969258665292,"score_spread":0.2222438012652853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}