{"id":"W1980772387","doi":"10.1021/np0702281","title":"Trypanocidal and Antileishmanial Dihydrochelerythrine Derivatives from <i>Garcinia lucida</i>","year":2007,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Traditional and Medicinal Uses of Annonaceae","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Antiprotozoal; Semisynthesis; Leishmania donovani; Trypanosoma brucei; Trypanocidal agent; Biology; Phenanthridine; Traditional medicine; Stereochemistry; Chemistry; Leishmaniasis; Biochemistry; In vitro; Medicine; Visceral leishmaniasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002157095,0.0001345723,0.0001882745,0.00005569265,0.00005361158,0.00001495605,0.0001358431,0.00007546882,0.000006539964],"category_scores_gemma":[0.0002404861,0.0001007323,0.00006298564,0.00008093502,0.0001217796,0.00001926973,0.00004869218,0.0002423639,0.000001614466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009350028,"about_ca_system_score_gemma":0.00006939054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006894204,"about_ca_topic_score_gemma":0.000007211419,"domain_scores_codex":[0.9990633,0.00002121841,0.0002996802,0.0001975356,0.0002345169,0.0001837142],"domain_scores_gemma":[0.9992896,0.00002976739,0.0002135593,0.0001075983,0.0002535502,0.0001059476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001241087,0.00006260286,0.001060027,0.00001247234,0.00008049289,0.0000555009,0.00006953225,7.266716e-7,0.9885429,0.0000381276,0.005219736,0.003616836],"study_design_scores_gemma":[0.002472405,0.0007972621,0.1911516,0.00005076275,0.00004147907,0.0006093598,0.0001025211,0.000001609016,0.7483772,0.0002794498,0.05592696,0.0001893756],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990965,0.006222967,0.00008593781,0.001678034,0.0007391612,0.00007855094,0.000008025328,0.000004325519,0.000218012],"genre_scores_gemma":[0.992946,0.000385975,0.002192772,0.0004954064,0.003670537,3.103983e-7,0.00002952073,0.00001197546,0.0002674483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2401656,"threshold_uncertainty_score":0.4107745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006279114168643391,"score_gpt":0.2301809592347485,"score_spread":0.2239018450661051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}