{"id":"W1980772387","doi":"10.1021/np0702281","title":"Trypanocidal and Antileishmanial Dihydrochelerythrine Derivatives from <i>Garcinia lucida</i>","year":2007,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Traditional and Medicinal Uses of Annonaceae","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Antiprotozoal; Semisynthesis; Leishmania donovani; Trypanosoma brucei; Trypanocidal agent; Biology; Phenanthridine; Traditional medicine; Stereochemistry; Chemistry; Leishmaniasis; Biochemistry; In vitro; Medicine; Visceral leishmaniasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006386488,0.0003960576,0.0001871079,0.0002792312,0.0001368718,0.0001191131,0.0001527302,0.0001692664,0.0009127968],"category_scores_gemma":[0.00006248104,0.00007653265,0.0001262305,0.00021297,0.0001394104,0.0001501628,0.000106791,0.0002653479,0.0002536381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001844337,"about_ca_system_score_gemma":0.0001366562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005917642,"about_ca_topic_score_gemma":0.001412496,"domain_scores_codex":[0.9999679,0.000006342034,0.000003126158,0.000006451633,0.000009082985,0.000007130383],"domain_scores_gemma":[0.9999623,0.000004528525,0.00001200305,0.000003997015,0.000006057027,0.00001105128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001161036,0.00001859959,0.0002110964,0.0001391227,0.000008263496,0.00008334254,0.00003075882,0.00007909036,0.9949366,0.00008661948,0.00005396494,0.004236361],"study_design_scores_gemma":[0.00007120574,0.001335481,0.02009972,0.00002769341,0.00007294351,0.0006892552,0.00003954585,0.0002316018,0.9666654,0.00008294618,0.01066432,0.00001986697],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818589,0.01085053,0.001348646,0.0001498258,0.00003106734,0.00004958991,0.0009162313,0.0001323634,0.004662958],"genre_scores_gemma":[0.9907593,0.003733214,0.002501299,0.00009735864,0.00002843113,0.00001656716,0.001076123,0.00001104744,0.001776661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009127968,"threshold_uncertainty_score":0.003053546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006279114168643391,"score_gpt":0.2301809592347485,"score_spread":0.2239018450661051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}