{"id":"W1980779249","doi":"10.1016/s0924-977x(01)00101-8","title":"Review of pharmacokinetic and pharmacodynamic interaction studies with citalopram","year":2001,"lang":"en","type":"review","venue":"European Neuropsychopharmacology","topic":"Treatment of Major Depression","field":"Medicine","cited_by":138,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre; University of Toronto; Women's College Hospital; Health Sciences Centre","funders":"","keywords":"Citalopram; Pharmacology; Mephenytoin; Triazolam; CYP2C19; Pharmacokinetics; Chemistry; Carbamazepine; CYP2D6; Drug interaction; Pharmacodynamics; Medicine; Benzodiazepine; Serotonin; Epilepsy; Cytochrome P450; Biochemistry; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003809428,0.0008538524,0.002894012,0.0004852274,0.00005386079,0.000009811207,0.0002647515,0.00008339305,0.0002522748],"category_scores_gemma":[0.00009183993,0.0005800284,0.0003813392,0.0006983228,0.0003299416,0.0001077218,0.0002213601,0.000967536,0.0001139365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001065294,"about_ca_system_score_gemma":0.00009286929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":9.3366e-7,"about_ca_topic_score_gemma":1.524148e-7,"domain_scores_codex":[0.9956291,0.001477892,0.001196976,0.000980812,0.0003085288,0.0004067087],"domain_scores_gemma":[0.9975302,0.0003847583,0.001089888,0.000509267,0.0002195976,0.0002663393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000275403,0.0003567749,0.000007370602,0.1715355,0.001416154,0.002154309,0.00002062622,5.158753e-7,0.0003609007,8.902203e-7,0.01264406,0.8112275],"study_design_scores_gemma":[0.002843636,0.0009432239,0.00005453193,0.1452226,0.01148164,0.005776474,0.000005789876,0.000004369242,0.000004310205,4.567889e-7,0.8333319,0.0003310407],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005154256,0.9882348,0.000002643257,0.0002351216,0.001151008,0.002478222,0.00002430798,0.0002732434,0.007085232],"genre_scores_gemma":[0.00009338173,0.9958814,0.0001110511,0.002241943,0.0004173377,0.0001089962,0.00008496662,0.0003722251,0.0006886318],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8206878,"threshold_uncertainty_score":0.9996651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07500099455512174,"score_gpt":0.4354639798496608,"score_spread":0.3604629852945391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}