{"id":"W1980799154","doi":"10.1021/cb700214x","title":"Signaling by Committee: Receptor Clusters Determine Pathways of Cellular Activation","year":2007,"lang":"en","type":"letter","venue":"ACS Chemical Biology","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Glycomics Centre; University of Alberta","funders":"","keywords":"Receptor; Signal transduction; Cell biology; Mechanism (biology); Cell signaling; Biology; Cluster analysis; Computational biology; Chemistry; Biochemistry; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009289228,0.0004693296,0.0005150415,0.0002596024,0.001127115,0.001865823,0.0005396619,0.007007859,0.009461743],"category_scores_gemma":[0.003481904,0.0003279383,0.0004429008,0.0001941232,0.001104176,0.0009312623,0.0004825942,0.00771807,0.009131189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001993839,"about_ca_system_score_gemma":0.0004801903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004718733,"about_ca_topic_score_gemma":0.0007567923,"domain_scores_codex":[0.99913,0.000200211,0.00007395645,0.0001690834,0.0003434196,0.00008348463],"domain_scores_gemma":[0.9987807,0.000603795,0.0000741465,0.00008718966,0.0003247927,0.000129363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0009233269,0.00008990007,0.001136656,0.0002475799,0.00003917844,0.002468972,0.000112258,0.0002664195,0.018806,0.0220144,0.8958462,0.05804909],"study_design_scores_gemma":[0.0005753003,0.0003744725,0.002901908,0.0001657438,0.0000637112,0.004244021,0.0002692146,0.003434667,0.03543788,0.02536462,0.927088,0.00008052389],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01516764,0.01019882,0.004393457,0.877995,0.05206624,0.0001029347,0.0003403781,0.0003127705,0.0394228],"genre_scores_gemma":[0.1633069,0.01996605,0.005396459,0.6000778,0.08309672,0.0004101068,0.0005418296,0.0002096621,0.1269945],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.009461743,"threshold_uncertainty_score":0.03165263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03205915763733814,"score_gpt":0.2866188323451475,"score_spread":0.2545596747078094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}