{"id":"W1980799154","doi":"10.1021/cb700214x","title":"Signaling by Committee: Receptor Clusters Determine Pathways of Cellular Activation","year":2007,"lang":"en","type":"letter","venue":"ACS Chemical Biology","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Glycomics Centre; University of Alberta","funders":"","keywords":"Receptor; Signal transduction; Cell biology; Mechanism (biology); Cell signaling; Biology; Cluster analysis; Computational biology; Chemistry; Biochemistry; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0003043102,0.0002822653,0.0007328757,0.0002894896,0.0000150757,0.00000425386,0.0002883329,0.001829742,0.0003261333],"category_scores_gemma":[0.0004081264,0.0002505447,0.0001457921,0.0002622941,0.0002708752,0.0000177793,0.0001652182,0.002181822,0.00004410072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000205148,"about_ca_system_score_gemma":0.00008245353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003897963,"about_ca_topic_score_gemma":3.388685e-7,"domain_scores_codex":[0.9978608,0.0001331418,0.0006293469,0.0005127988,0.0003123693,0.0005515781],"domain_scores_gemma":[0.9983534,0.0007716867,0.0002228257,0.0004284118,0.0001299584,0.00009376859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001483921,0.00005536853,0.0001913177,0.0002082472,0.00002743833,0.00006012337,0.00001970899,4.466785e-8,0.7031599,7.363464e-7,0.2940694,0.002059374],"study_design_scores_gemma":[0.0008237449,0.0001715087,0.000003058546,0.000131882,0.00001875638,0.000007485287,0.000009331266,0.0000123504,0.7834269,0.00002678209,0.2152083,0.0001598853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8761941,0.0003554377,0.0005129839,0.1210959,0.0001379385,0.0007573338,0.00007518312,0.00004611639,0.0008249744],"genre_scores_gemma":[0.5188581,0.0001895498,0.002315456,0.4589033,0.002309841,0.00007731457,0.01578473,0.0001884556,0.001373269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.357336,"threshold_uncertainty_score":0.9999947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03205915763733814,"score_gpt":0.2866188323451475,"score_spread":0.2545596747078094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}