{"id":"W1980813169","doi":"10.1080/14756360310001624975","title":"Cytotoxic and Topographical Properties of 6-Arylidene-2-dimethylaminomethylcyclohexanone Hydrochlorides and Related Compounds","year":2004,"lang":"en","type":"article","venue":"Journal of Enzyme Inhibition and Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Cytotoxicity; Chemistry; L1210 cells; Stereochemistry; Cytotoxic T cell; Cell culture; Mannich reaction; Aryl; Biochemistry; In vitro; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000935912,0.0001964355,0.0001763697,0.0002289651,0.0001281916,0.0001467051,0.0001158558,0.0001409561,0.001682127],"category_scores_gemma":[0.0001813325,0.00007712124,0.0001018844,0.0001735756,0.0001448925,0.000115162,0.00008810308,0.0001995989,0.0002488009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001374686,"about_ca_system_score_gemma":0.0001141713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007972243,"about_ca_topic_score_gemma":0.001029981,"domain_scores_codex":[0.999921,0.00001831881,0.00001047042,0.00001246276,0.00002225663,0.00001552368],"domain_scores_gemma":[0.9998815,0.00003636537,0.00002648838,0.00001258733,0.00002001306,0.00002302156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003290179,0.00006374848,0.0003548312,0.00006172814,0.00000557982,0.0000953651,0.0000274908,0.0008175174,0.9938102,0.00009778838,0.00004446251,0.004292354],"study_design_scores_gemma":[0.00002480688,0.001537996,0.004299551,0.000006503781,0.00001399333,0.0001929982,0.00002746474,0.0006654722,0.9920551,0.00002521119,0.001143759,0.000007085506],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940554,0.002141968,0.0003900223,0.00003320446,0.00001933109,0.00002127535,0.0002330979,0.00001668922,0.003089025],"genre_scores_gemma":[0.9957094,0.001449995,0.0005259814,0.00001800837,0.00001239311,0.00001678549,0.0003277276,0.000006053013,0.001933698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001682127,"threshold_uncertainty_score":0.005627275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01473039548903411,"score_gpt":0.2163620841216082,"score_spread":0.2016316886325741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}