{"id":"W1980838685","doi":"10.1371/journal.pone.0064613","title":"Production of Cloned Pigs with Targeted Attenuation of Gene Expression","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Animal Genetics and Reproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; McGill University","keywords":"Biology; Somatic cell nuclear transfer; Molecular biology; Small hairpin RNA; RNA interference; Transfection; Expression vector; Viral vector; Gene expression; Transgene; Gene; RNA; Cell biology; Embryo; Genetics; Embryogenesis; Blastocyst; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007365486,0.0004629357,0.0005330802,0.0005047243,0.0002058072,0.0005030317,0.0005982099,0.0007651563,0.00281583],"category_scores_gemma":[0.0004233699,0.0003556182,0.0007071108,0.0002082422,0.0004000939,0.0002983658,0.0004369644,0.0007942682,0.001050211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002475647,"about_ca_system_score_gemma":0.0003460342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003126742,"about_ca_topic_score_gemma":0.0005369812,"domain_scores_codex":[0.9995604,0.00009186978,0.00005408013,0.0001095518,0.0001157914,0.000068267],"domain_scores_gemma":[0.9994882,0.0001597793,0.0001500587,0.00007956456,0.00005618213,0.00006620567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008406599,0.00005936136,0.0002514617,0.00007538711,0.00001690318,0.0002239674,0.00003701174,0.00007175734,0.9964205,0.0002758343,0.00006955445,0.002414258],"study_design_scores_gemma":[0.0001333807,0.002260792,0.006985791,0.0000592568,0.0001826864,0.002195492,0.00007486883,0.001784515,0.9662644,0.0001586983,0.01987581,0.00002440472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.894472,0.002509252,0.09151679,0.0004157402,0.0006070823,0.0009154038,0.002029399,0.001017773,0.006516613],"genre_scores_gemma":[0.9006681,0.003917567,0.06503696,0.0003733802,0.0001255902,0.0009373045,0.005187107,0.0004900941,0.02326394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00281583,"threshold_uncertainty_score":0.009419918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01758317785292699,"score_gpt":0.2025458696217412,"score_spread":0.1849626917688142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}