{"id":"W1980838685","doi":"10.1371/journal.pone.0064613","title":"Production of Cloned Pigs with Targeted Attenuation of Gene Expression","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Animal Genetics and Reproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; McGill University","keywords":"Biology; Somatic cell nuclear transfer; Molecular biology; Small hairpin RNA; RNA interference; Transfection; Expression vector; Viral vector; Gene expression; Transgene; Gene; RNA; Cell biology; Embryo; Genetics; Embryogenesis; Blastocyst; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006589329,0.00007050025,0.0001110603,0.00002905877,0.00002445452,0.000002924596,0.00005176404,0.00006558577,0.00002318129],"category_scores_gemma":[0.00004718017,0.00005573045,0.00002256388,0.0000710032,0.00005424516,0.000004459291,0.00002118257,0.00003144266,0.000003934928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003664697,"about_ca_system_score_gemma":0.0000204017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001799618,"about_ca_topic_score_gemma":0.000001727558,"domain_scores_codex":[0.9993511,0.00002308539,0.0001600063,0.0002261825,0.0001589455,0.00008069575],"domain_scores_gemma":[0.9992273,0.000001485759,0.0001483309,0.0002547986,0.0003436506,0.00002446868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009654006,0.000423437,0.005982177,0.00005785911,0.00006127001,4.366905e-8,0.0000412683,0.00005181777,0.992913,0.000002523146,0.0001504513,0.000219631],"study_design_scores_gemma":[0.0001786524,0.0005510029,0.02471204,0.00004292533,0.00003434378,0.000001086242,0.00003763543,0.00002794239,0.9743007,0.00001801513,0.00002579597,0.00006989956],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986451,0.0002885692,0.0004983091,0.0001212886,0.000031027,0.0003081731,0.000002783303,0.000005715243,0.00009905387],"genre_scores_gemma":[0.9886833,0.0001149073,0.01026194,0.000007515514,0.000172004,0.00002761022,0.00008261449,0.00001278265,0.000637335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01872986,"threshold_uncertainty_score":0.2272622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01758317785292699,"score_gpt":0.2025458696217412,"score_spread":0.1849626917688142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}