{"id":"W1980841783","doi":"10.1002/biot.200600001","title":"Inhibitors of human indoleamine 2,3‐dioxygenase identified with a target‐based screen in yeast","year":2006,"lang":"en","type":"article","venue":"Biotechnology Journal","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Indoleamine 2,3-dioxygenase; Yeast; Computational biology; Biology; Chemistry; Microbiology; Biochemistry; Tryptophan","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001875338,0.0001554928,0.000231176,0.0007552736,0.0001297495,0.00002867826,0.0003770543,0.0002479925,0.00006187878],"category_scores_gemma":[0.0001147751,0.0001275857,0.0000641817,0.0007478471,0.0005342252,0.0001093221,0.00004985406,0.0005498127,0.00001105476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004103966,"about_ca_system_score_gemma":0.0000758875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006922867,"about_ca_topic_score_gemma":0.0001825324,"domain_scores_codex":[0.9986676,0.00007658164,0.0003960236,0.0002724872,0.0002506555,0.0003366785],"domain_scores_gemma":[0.9993989,0.00002886062,0.0002641223,0.0002307673,0.00002964204,0.00004770707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007700991,0.0002562297,0.002722416,0.000008452278,0.000003188495,0.0002020001,0.00001530092,0.0001159443,0.9940012,0.001609743,0.0004432682,0.0005452659],"study_design_scores_gemma":[0.002055945,0.0002543171,0.01115876,0.0000636536,0.000002195624,0.0001405612,0.00008628002,0.00007651999,0.9843856,0.001279361,0.0003505248,0.0001463125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974475,0.00009102078,0.0008086785,0.0008653242,0.000068591,0.0001407511,0.00001132869,0.00007693229,0.0004898626],"genre_scores_gemma":[0.9990358,0.000005661477,0.000671425,0.0001153235,0.00005791177,0.000003674792,0.000002375597,0.00001932222,0.00008855163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009615617,"threshold_uncertainty_score":0.5202794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01326167129158189,"score_gpt":0.2355206888263397,"score_spread":0.2222590175347578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}