{"id":"W1980866072","doi":"10.1111/j.1747-0285.2008.00720.x","title":"Potent Opioid Peptide Agonists Containing 4′‐[<i>N</i>‐((4′‐phenyl)‐phenethyl)carboxamido]phenylalanine (Bcp) in Place of Tyr","year":2008,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Institute on Drug Abuse; National Institutes of Health","keywords":"Chemistry; Dynorphin; Stereochemistry; Dynorphin A; Agonist; Nociceptin receptor; Opioid peptide; Peptide; Opioid receptor; Receptor; Phenylalanine; Substituent; Partial agonist; Opioid; Biochemistry; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002566763,0.0003996308,0.0007642698,0.0001231484,0.0001129453,0.00001032051,0.0006886444,0.0002220611,0.00005715627],"category_scores_gemma":[0.0006998008,0.0003518127,0.0001655516,0.0003915468,0.0009848295,0.00009531416,0.0002737243,0.0005530133,0.00008156242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007423584,"about_ca_system_score_gemma":0.0001311511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006815275,"about_ca_topic_score_gemma":0.000003030058,"domain_scores_codex":[0.996881,0.0004640058,0.000718054,0.0009687071,0.0001781875,0.0007900212],"domain_scores_gemma":[0.9979086,0.001136034,0.0002732606,0.0004325894,0.00005770894,0.0001918152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005296806,0.000191825,0.001620338,0.00001999722,0.000009150745,0.0001230529,0.0003050383,0.000145742,0.9948741,0.0005884862,0.0008676117,0.0007249322],"study_design_scores_gemma":[0.001187049,0.0004099084,0.001269122,0.00004212868,0.00001145128,0.0001069047,0.00004299376,0.0003355479,0.9928983,0.001335068,0.00198687,0.0003746077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976228,0.0003171048,0.0001149341,0.0001756561,0.0001910881,0.0003628555,0.00002007366,0.0001095534,0.001085955],"genre_scores_gemma":[0.9969554,0.0003708835,0.001037377,0.001177146,0.0001577451,0.00003846935,0.00001676365,0.00004646901,0.0001997708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001975798,"threshold_uncertainty_score":0.9998934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04220195441164158,"score_gpt":0.2542822981278303,"score_spread":0.2120803437161887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}