{"id":"W1980866072","doi":"10.1111/j.1747-0285.2008.00720.x","title":"Potent Opioid Peptide Agonists Containing 4′‐[<i>N</i>‐((4′‐phenyl)‐phenethyl)carboxamido]phenylalanine (Bcp) in Place of Tyr","year":2008,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Institute on Drug Abuse; National Institutes of Health","keywords":"Chemistry; Dynorphin; Stereochemistry; Dynorphin A; Agonist; Nociceptin receptor; Opioid peptide; Peptide; Opioid receptor; Receptor; Phenylalanine; Substituent; Partial agonist; Opioid; Biochemistry; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001054178,0.000360044,0.0003214515,0.00009018643,0.00009499059,0.0001662867,0.0002230896,0.0001965607,0.00108303],"category_scores_gemma":[0.00009888523,0.0001382719,0.0001340612,0.0001421388,0.0001318953,0.0001661183,0.0001569535,0.0004076209,0.0003875162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000185682,"about_ca_system_score_gemma":0.0001587411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000338526,"about_ca_topic_score_gemma":0.0008524672,"domain_scores_codex":[0.9999021,0.00001484802,0.000007150391,0.00001920608,0.00002050659,0.00003614473],"domain_scores_gemma":[0.9998978,0.00002434188,0.00002754403,0.00000658219,0.00000981301,0.00003387186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000158973,0.00003213249,0.00006754592,0.00004955513,0.000004928998,0.00003533475,0.000007154592,0.00007744104,0.9978359,0.00003676753,0.000033622,0.001660659],"study_design_scores_gemma":[0.00006344272,0.001503092,0.002446315,0.000006840767,0.00002728685,0.0003602003,0.00001726651,0.0004394828,0.9922936,0.0000220094,0.002811321,0.000009092132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919227,0.002750758,0.002170712,0.00004074477,0.00002879983,0.00005338003,0.0003729753,0.00004560883,0.002614172],"genre_scores_gemma":[0.9904399,0.001720445,0.00452939,0.00009241304,0.00003107706,0.00006804201,0.0006875922,0.00001833131,0.002412805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00108303,"threshold_uncertainty_score":0.003623068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04220195441164158,"score_gpt":0.2542822981278303,"score_spread":0.2120803437161887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}