{"id":"W1980900700","doi":"10.1021/bp060187j","title":"High‐Level Recombinant Protein Production in CHO Cells Using an Adenoviral Vector and the Cumate Gene‐Switch","year":2006,"lang":"en","type":"article","venue":"Biotechnology Progress","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique; Université Laval; National Research Council Canada; Université de Montréal; Biotechnology Research Institute","funders":"","keywords":"Chinese hamster ovary cell; Transduction (biophysics); Internal ribosome entry site; Biology; Cell culture; Molecular biology; Green fluorescent protein; Adenoviridae; Adenovirus infection; Recombinant DNA; Protein biosynthesis; Gene; Virology; Messenger RNA; Translation (biology); Biochemistry; Virus; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002324814,0.000201846,0.0001912073,0.00009746937,0.0001937899,0.00004498343,0.0002123913,0.0004282409,0.000004156464],"category_scores_gemma":[0.00002846742,0.0001478091,0.00004942589,0.0001794519,0.0005400458,0.00001218664,0.0001788346,0.0001803838,0.000002562389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002521009,"about_ca_system_score_gemma":0.000045386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004270537,"about_ca_topic_score_gemma":0.0001292815,"domain_scores_codex":[0.9986432,0.0001244201,0.0002599757,0.0005431211,0.00009585683,0.0003334514],"domain_scores_gemma":[0.9993048,0.000002593271,0.0001441829,0.0004619471,0.00004808941,0.00003837041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000256947,0.0002412524,0.001389669,0.00002380218,0.00001708766,0.000007357368,0.00001339951,0.0001153625,0.9932185,0.0008413716,0.0001456372,0.003729549],"study_design_scores_gemma":[0.001329878,0.0002646603,0.002150067,0.00003292058,0.00001539381,0.00004524945,0.00002727676,0.0001812564,0.9934019,0.001374125,0.0009557537,0.0002214961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995868,0.001594067,0.0001700543,0.0008394084,0.000437798,0.001009789,0.00001297083,0.0000605377,0.000007359953],"genre_scores_gemma":[0.9976813,0.0001070725,0.001468487,0.00003654127,0.0002406213,0.0002435801,0.00003628549,0.00002765082,0.00015851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003508053,"threshold_uncertainty_score":0.6027479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01220274224225722,"score_gpt":0.2440820804881871,"score_spread":0.2318793382459299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}