{"id":"W1980900700","doi":"10.1021/bp060187j","title":"High‐Level Recombinant Protein Production in CHO Cells Using an Adenoviral Vector and the Cumate Gene‐Switch","year":2006,"lang":"en","type":"article","venue":"Biotechnology Progress","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique; Université Laval; National Research Council Canada; Université de Montréal; Biotechnology Research Institute","funders":"","keywords":"Chinese hamster ovary cell; Transduction (biophysics); Internal ribosome entry site; Biology; Cell culture; Molecular biology; Green fluorescent protein; Adenoviridae; Adenovirus infection; Recombinant DNA; Protein biosynthesis; Gene; Virology; Messenger RNA; Translation (biology); Biochemistry; Virus; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006993199,0.0007950815,0.0007485928,0.0004991264,0.0003164592,0.0007680627,0.0005917935,0.0004954474,0.0009746788],"category_scores_gemma":[0.0003376289,0.0003059437,0.0007109735,0.0006222628,0.0003940433,0.0004827262,0.000656962,0.001102838,0.001349116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000582843,"about_ca_system_score_gemma":0.0004628343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001190557,"about_ca_topic_score_gemma":0.00106883,"domain_scores_codex":[0.9995915,0.00006623929,0.00007108058,0.00008865428,0.0001257466,0.00005674929],"domain_scores_gemma":[0.9998136,0.00003922082,0.00003338884,0.00004210506,0.00004515865,0.00002649871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002965762,0.00001286091,0.00005457884,0.00005396351,0.000005821259,0.00003369509,0.00001914464,0.00005348467,0.9986386,0.0001174195,0.00004620659,0.0009346713],"study_design_scores_gemma":[0.00002291478,0.0001373339,0.000459829,0.000009159398,0.00002285622,0.0001421755,0.00001630367,0.0007463253,0.9902554,0.00006666639,0.008110031,0.0000109836],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7561626,0.00570162,0.2197065,0.0005055199,0.0004217866,0.00124668,0.005504295,0.002231553,0.008519494],"genre_scores_gemma":[0.728644,0.007489716,0.2364229,0.0001944266,0.000111809,0.001042656,0.01170432,0.0006818091,0.01370847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001190557,"threshold_uncertainty_score":0.00422883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01220274224225722,"score_gpt":0.2440820804881871,"score_spread":0.2318793382459299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}