{"id":"W1980904413","doi":"10.1006/bbrc.2001.5536","title":"Differential Effects of Filipin and Methyl-β-cyclodextrin on B Cell Receptor Signaling","year":2001,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Filipin; Lipid raft; Signal transduction; Cell biology; Chemistry; Phosphorylation; Calcium; Cyclodextrin; Receptor; Biochemistry; Biophysics; Biology; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001055075,0.0001253989,0.0001637325,0.0000556663,0.0001533266,0.00002272041,0.0003665194,0.000144035,0.00001403119],"category_scores_gemma":[0.0001958195,0.00009897386,0.00006509339,0.000170196,0.000588219,0.000003828642,0.0004386558,0.0002901493,0.000004182255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007615943,"about_ca_system_score_gemma":0.00002989164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000268051,"about_ca_topic_score_gemma":0.000001500805,"domain_scores_codex":[0.9989064,0.000182516,0.0001606818,0.0002897586,0.0002224749,0.0002381392],"domain_scores_gemma":[0.998768,0.0002806889,0.00003680689,0.0006405844,0.0001168061,0.0001571346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001097658,0.0003070228,0.0001278627,0.00006420994,0.00001453426,3.765896e-7,0.00002322859,4.926262e-8,0.9950613,0.0002858497,0.0003770454,0.003628736],"study_design_scores_gemma":[0.0004221983,0.000392646,0.0006776414,0.00003799804,0.0000177722,0.000001448062,0.0000249705,0.0000179128,0.9932218,0.00008631597,0.00498637,0.0001129934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984844,0.0004425203,0.00002619998,0.0004259283,0.00002639234,0.0002141747,0.00001883556,0.000007396192,0.0003541265],"genre_scores_gemma":[0.9966082,0.002171677,0.0005715658,0.00003409074,0.00016393,0.00003753468,0.0001005833,0.00001186138,0.0003005455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004609325,"threshold_uncertainty_score":0.4036037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03175322528930683,"score_gpt":0.3356972101261405,"score_spread":0.3039439848368336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}