{"id":"W1980912145","doi":"10.1093/nar/gku564","title":"Analysis of neonatal brain lacking ATRX or MeCP2 reveals changes in nucleosome density, CTCF binding and chromatin looping","year":2014,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Western Ontario; Children’s Health Research Institute; Western University","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"ATRX; CTCF; Biology; Chromatin; Nucleosome; MECP2; Genomic imprinting; Genetics; Cell biology; Gene; Gene expression; DNA methylation; Mutation; Phenotype; Enhancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001038383,0.0002902973,0.0002284919,0.00042445,0.0001422092,0.0001766451,0.0003163,0.0001791947,0.00212525],"category_scores_gemma":[0.0001469701,0.0001771484,0.0001968187,0.0001926358,0.0003275356,0.0001414054,0.000268533,0.0004561946,0.000368662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002987615,"about_ca_system_score_gemma":0.0002509307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002444461,"about_ca_topic_score_gemma":0.003439882,"domain_scores_codex":[0.9999026,0.000006827288,0.000008513902,0.00002456874,0.00003492871,0.00002259248],"domain_scores_gemma":[0.9998485,0.00003309259,0.00003871673,0.00001192462,0.00001768682,0.00005008019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00005914786,0.000006152284,0.0003950442,0.00001944533,0.000005585043,0.0001019353,0.00001518356,0.00001725888,0.9987274,0.00004054823,0.00001396095,0.0005982916],"study_design_scores_gemma":[0.000008458387,0.0001311806,0.04227291,0.00001189772,0.00002553766,0.001049991,0.0001035348,0.0004942752,0.9549525,0.00008964883,0.0008543556,0.000005888126],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910483,0.002104973,0.003803879,0.00007171003,0.00003376904,0.00001206897,0.001202623,0.000080918,0.001641795],"genre_scores_gemma":[0.9905685,0.001317013,0.002729848,0.00006582792,0.000007181239,0.0000403144,0.00170283,0.00005300188,0.003515479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002444461,"threshold_uncertainty_score":0.007109702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03480070923182713,"score_gpt":0.3268125693049665,"score_spread":0.2920118600731394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}